Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Jaemoon Yang, Tong Il Lee, Jaemin Lee, Eun Kyung Lim, Woochan Hyung, Choong Hwan Lee, Yong Jin Song, Jinsuck Suh, Ho Geun Yoon, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

Original languageEnglish
Pages (from-to)3870-3876
Number of pages7
JournalChemistry of Materials
Volume19
Issue number16
DOIs
Publication statusPublished - 2007 Aug 7

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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