Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

Jaemoon Yang, Tong Il Lee, Jaemin Lee, Eun Kyung Lim, Woochan Hyung, Choong Hwan Lee, Yong Jin Song, Jinsuck Suh, Ho Geun Yoon, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

Original languageEnglish
Pages (from-to)3870-3876
Number of pages7
JournalChemistry of Materials
Volume19
Issue number16
DOIs
Publication statusPublished - 2007 Aug 7

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Magnetic resonance
Fatty acids
Contrast Media
Polyethylene glycols
Fatty Acids
Imaging techniques
Cytotoxicity
Nanocrystals
Block copolymers
Animals
Nanoparticles
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Yang, Jaemoon ; Lee, Tong Il ; Lee, Jaemin ; Lim, Eun Kyung ; Hyung, Woochan ; Lee, Choong Hwan ; Song, Yong Jin ; Suh, Jinsuck ; Yoon, Ho Geun ; Huh, yongmin ; Haam, Seungjoo. / Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid. In: Chemistry of Materials. 2007 ; Vol. 19, No. 16. pp. 3870-3876.
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Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid. / Yang, Jaemoon; Lee, Tong Il; Lee, Jaemin; Lim, Eun Kyung; Hyung, Woochan; Lee, Choong Hwan; Song, Yong Jin; Suh, Jinsuck; Yoon, Ho Geun; Huh, yongmin; Haam, Seungjoo.

In: Chemistry of Materials, Vol. 19, No. 16, 07.08.2007, p. 3870-3876.

Research output: Contribution to journalArticle

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T1 - Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid

AU - Yang, Jaemoon

AU - Lee, Tong Il

AU - Lee, Jaemin

AU - Lim, Eun Kyung

AU - Hyung, Woochan

AU - Lee, Choong Hwan

AU - Song, Yong Jin

AU - Suh, Jinsuck

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AU - Huh, yongmin

AU - Haam, Seungjoo

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AB - Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.

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