Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications

Eun Kyung Lim; Jaemoon Yang; Mee ye Park; Joseph Park; Jin Suck Suh; Ho Geun Yoon; Yong Min Huh; Seungjoo Haam

doi:10.1016/j.colsurfb.2008.01.006

Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications

Eun Kyung Lim, Jaemoon Yang, Mee ye Park, Joseph Park, Jin Suck Suh, Ho Geun Yoon, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We report the successful fabrication of the various types of water soluble PEGylated magnetic complexes (PMCs) for magnetism-related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in vitro model. Our results demonstrated that our PMCs possessed the potential for highly efficient magnetism-related biomedical applications such as MR image agents, drug delivery and tracking of cells.

Original language	English
Pages (from-to)	111-117
Number of pages	7
Journal	Colloids and Surfaces B: Biointerfaces
Volume	64
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2008.01.006
Publication status	Published - 2008 Jun 15

Bibliographical note

Funding Information:
This work was supported by Korea Science and Engineering Foundation (KOSEF) (R15-2004-024-00000-0, M10755020001-07N5502-00110 and R01-2006-000-10023-0) and a grant of the National R&D Program for Cancer Control, Korea Ministry of Health & Welfare (0620190-1).

All Science Journal Classification (ASJC) codes

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfb.2008.01.006

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title = "Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications",

abstract = "We report the successful fabrication of the various types of water soluble PEGylated magnetic complexes (PMCs) for magnetism-related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in vitro model. Our results demonstrated that our PMCs possessed the potential for highly efficient magnetism-related biomedical applications such as MR image agents, drug delivery and tracking of cells.",

author = "Lim, {Eun Kyung} and Jaemoon Yang and Park, {Mee ye} and Joseph Park and Suh, {Jin Suck} and Yoon, {Ho Geun} and Huh, {Yong Min} and Seungjoo Haam",

note = "Funding Information: This work was supported by Korea Science and Engineering Foundation (KOSEF) (R15-2004-024-00000-0, M10755020001-07N5502-00110 and R01-2006-000-10023-0) and a grant of the National R&D Program for Cancer Control, Korea Ministry of Health & Welfare (0620190-1).",

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AU - Lim, Eun Kyung

AU - Yang, Jaemoon

AU - Park, Mee ye

AU - Park, Joseph

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Huh, Yong Min

AU - Haam, Seungjoo

N1 - Funding Information: This work was supported by Korea Science and Engineering Foundation (KOSEF) (R15-2004-024-00000-0, M10755020001-07N5502-00110 and R01-2006-000-10023-0) and a grant of the National R&D Program for Cancer Control, Korea Ministry of Health & Welfare (0620190-1).

PY - 2008/6/15

Y1 - 2008/6/15

N2 - We report the successful fabrication of the various types of water soluble PEGylated magnetic complexes (PMCs) for magnetism-related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in vitro model. Our results demonstrated that our PMCs possessed the potential for highly efficient magnetism-related biomedical applications such as MR image agents, drug delivery and tracking of cells.

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Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications

Abstract

Bibliographical note

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