Synthetic K + /Cl - -selective symporter across a phospholipid membrane

Jung Ha Lee, Ji Hyun Lee, Ye Rin Choi, Philjae Kang, Moon-Gun Choi, Kyu-Sung Jeong

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Synthetic molecules which selectively transport sodium or potassium chloride across a lipid membrane have been prepared. The salt carriers consist of two heteroditopic binding sites, an anion-binding cavity with three hydrogen bond donors and an azacrown ether for binding an alkali metal cation. The association constants between the carriers and chloride ion have been enhanced by 1 order of the magnitude in the presence of sodium or potassium ion in 10% (v/v) CD 3 OH/CD 3 CN, due to the formation of a contact ion-pair between the bound cation and chloride as demonstrated by the single-crystal X-ray structure of a sodium chloride complex. A series of transport experiments have demonstrated that the synthetic molecule functions as a mobile carrier of transporting salts via M + /Cl - symport. Among alkali metal chlorides, the carrier with an 18-azacrown-6 exhibits a strong selectivity toward potassium chloride, while the carrier with a 15-azacrown-5 displays a moderate selectivity for sodium chloride.

Original languageEnglish
Pages (from-to)6403-6409
Number of pages7
JournalJournal of Organic Chemistry
Volume79
Issue number14
DOIs
Publication statusPublished - 2014 Jul 18

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Symporters
Sodium Chloride
Alkali Metals
Chlorides
Phospholipids
Potassium Chloride
Ions
Membranes
Cations
Salts
Molecules
Membrane Lipids
Ether
Anions
Potassium
Hydrogen bonds
Sodium
Display devices
Binding Sites
Association reactions

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Lee, Jung Ha ; Lee, Ji Hyun ; Choi, Ye Rin ; Kang, Philjae ; Choi, Moon-Gun ; Jeong, Kyu-Sung. / Synthetic K + /Cl - -selective symporter across a phospholipid membrane In: Journal of Organic Chemistry. 2014 ; Vol. 79, No. 14. pp. 6403-6409.
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Synthetic K + /Cl - -selective symporter across a phospholipid membrane . / Lee, Jung Ha; Lee, Ji Hyun; Choi, Ye Rin; Kang, Philjae; Choi, Moon-Gun; Jeong, Kyu-Sung.

In: Journal of Organic Chemistry, Vol. 79, No. 14, 18.07.2014, p. 6403-6409.

Research output: Contribution to journalArticle

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