Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy

Mun Kyung Sunwoo, Jin Yong Hong, Junjeong Choi, Hyun Jung Park, SeHoon Kim, philhyu Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The clinical characteristics of postoperative delirium are similar to core features of α-Synuclein-related cognitive disorders, such as dementia with Lewy bodies or Parkinson disease dementia. We therefore investigated the α-Synuclein pathology in patients who experienced postoperative delirium after gastrectomy for stomach cancer. Method: Patients with and without postoperative delirium were selected among patients undergoing total gastrectomy for primary gastric cancer from 2007 to 2011 (each n 5 16) at the university hospital. Immunohistochemical staining for α-Synuclein of both normal and phosphorylated form was performed in the myenteric plexus. A logistic regression analysis was applied to identify independent predictors of postoperative delirium. Results: No significant differences were observed for age, sex, operation time, or onset of delirium after total gastrectomy between patients with and without postoperative delirium. Patients with postoperative delirium had a higher frequency of intensive care unit admissions (43.8 vs 6.3%, p 5 0.037) and α-Synuclein-positive pathologies of normal (56.3 vs 12.5%, p 5 0.023) and phosphorylated form (43.8 vs 6.3%, p 5 0.037) compared with those without postoperative delirium. A logistic regression analysis revealed that immunoreactivity for normal α-Synuclein (odds ratio [OR] 9.20) and intensive care unit admission (OR 11.97) were independently associated with postoperative delirium. Conclusion: These results suggest that underlying α-Synuclein pathologies in the stomach are associated with postoperative delirium, implying that postoperative delirium represents a preclinical stage of α-Synuclein related to cognitive disorders.

Original languageEnglish
Pages (from-to)810-813
Number of pages4
JournalNeurology
Volume80
Issue number9
DOIs
Publication statusPublished - 2013 Feb 26

Fingerprint

Synucleins
Delirium
Gastrectomy
Pathology
Stomach Neoplasms
Intensive Care Units
Dementia
Logistic Models
Odds Ratio
Regression Analysis
Myenteric Plexus
Parkinson Disease

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Sunwoo, Mun Kyung ; Hong, Jin Yong ; Choi, Junjeong ; Park, Hyun Jung ; Kim, SeHoon ; Lee, philhyu. / Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy. In: Neurology. 2013 ; Vol. 80, No. 9. pp. 810-813.
@article{0b96ff022c004f0a9b9897199cd060e3,
title = "Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy",
abstract = "Objective: The clinical characteristics of postoperative delirium are similar to core features of α-Synuclein-related cognitive disorders, such as dementia with Lewy bodies or Parkinson disease dementia. We therefore investigated the α-Synuclein pathology in patients who experienced postoperative delirium after gastrectomy for stomach cancer. Method: Patients with and without postoperative delirium were selected among patients undergoing total gastrectomy for primary gastric cancer from 2007 to 2011 (each n 5 16) at the university hospital. Immunohistochemical staining for α-Synuclein of both normal and phosphorylated form was performed in the myenteric plexus. A logistic regression analysis was applied to identify independent predictors of postoperative delirium. Results: No significant differences were observed for age, sex, operation time, or onset of delirium after total gastrectomy between patients with and without postoperative delirium. Patients with postoperative delirium had a higher frequency of intensive care unit admissions (43.8 vs 6.3{\%}, p 5 0.037) and α-Synuclein-positive pathologies of normal (56.3 vs 12.5{\%}, p 5 0.023) and phosphorylated form (43.8 vs 6.3{\%}, p 5 0.037) compared with those without postoperative delirium. A logistic regression analysis revealed that immunoreactivity for normal α-Synuclein (odds ratio [OR] 9.20) and intensive care unit admission (OR 11.97) were independently associated with postoperative delirium. Conclusion: These results suggest that underlying α-Synuclein pathologies in the stomach are associated with postoperative delirium, implying that postoperative delirium represents a preclinical stage of α-Synuclein related to cognitive disorders.",
author = "Sunwoo, {Mun Kyung} and Hong, {Jin Yong} and Junjeong Choi and Park, {Hyun Jung} and SeHoon Kim and philhyu Lee",
year = "2013",
month = "2",
day = "26",
doi = "10.1212/WNL.0b013e3182840782",
language = "English",
volume = "80",
pages = "810--813",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy. / Sunwoo, Mun Kyung; Hong, Jin Yong; Choi, Junjeong; Park, Hyun Jung; Kim, SeHoon; Lee, philhyu.

In: Neurology, Vol. 80, No. 9, 26.02.2013, p. 810-813.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy

AU - Sunwoo, Mun Kyung

AU - Hong, Jin Yong

AU - Choi, Junjeong

AU - Park, Hyun Jung

AU - Kim, SeHoon

AU - Lee, philhyu

PY - 2013/2/26

Y1 - 2013/2/26

N2 - Objective: The clinical characteristics of postoperative delirium are similar to core features of α-Synuclein-related cognitive disorders, such as dementia with Lewy bodies or Parkinson disease dementia. We therefore investigated the α-Synuclein pathology in patients who experienced postoperative delirium after gastrectomy for stomach cancer. Method: Patients with and without postoperative delirium were selected among patients undergoing total gastrectomy for primary gastric cancer from 2007 to 2011 (each n 5 16) at the university hospital. Immunohistochemical staining for α-Synuclein of both normal and phosphorylated form was performed in the myenteric plexus. A logistic regression analysis was applied to identify independent predictors of postoperative delirium. Results: No significant differences were observed for age, sex, operation time, or onset of delirium after total gastrectomy between patients with and without postoperative delirium. Patients with postoperative delirium had a higher frequency of intensive care unit admissions (43.8 vs 6.3%, p 5 0.037) and α-Synuclein-positive pathologies of normal (56.3 vs 12.5%, p 5 0.023) and phosphorylated form (43.8 vs 6.3%, p 5 0.037) compared with those without postoperative delirium. A logistic regression analysis revealed that immunoreactivity for normal α-Synuclein (odds ratio [OR] 9.20) and intensive care unit admission (OR 11.97) were independently associated with postoperative delirium. Conclusion: These results suggest that underlying α-Synuclein pathologies in the stomach are associated with postoperative delirium, implying that postoperative delirium represents a preclinical stage of α-Synuclein related to cognitive disorders.

AB - Objective: The clinical characteristics of postoperative delirium are similar to core features of α-Synuclein-related cognitive disorders, such as dementia with Lewy bodies or Parkinson disease dementia. We therefore investigated the α-Synuclein pathology in patients who experienced postoperative delirium after gastrectomy for stomach cancer. Method: Patients with and without postoperative delirium were selected among patients undergoing total gastrectomy for primary gastric cancer from 2007 to 2011 (each n 5 16) at the university hospital. Immunohistochemical staining for α-Synuclein of both normal and phosphorylated form was performed in the myenteric plexus. A logistic regression analysis was applied to identify independent predictors of postoperative delirium. Results: No significant differences were observed for age, sex, operation time, or onset of delirium after total gastrectomy between patients with and without postoperative delirium. Patients with postoperative delirium had a higher frequency of intensive care unit admissions (43.8 vs 6.3%, p 5 0.037) and α-Synuclein-positive pathologies of normal (56.3 vs 12.5%, p 5 0.023) and phosphorylated form (43.8 vs 6.3%, p 5 0.037) compared with those without postoperative delirium. A logistic regression analysis revealed that immunoreactivity for normal α-Synuclein (odds ratio [OR] 9.20) and intensive care unit admission (OR 11.97) were independently associated with postoperative delirium. Conclusion: These results suggest that underlying α-Synuclein pathologies in the stomach are associated with postoperative delirium, implying that postoperative delirium represents a preclinical stage of α-Synuclein related to cognitive disorders.

UR - http://www.scopus.com/inward/record.url?scp=84876333515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876333515&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e3182840782

DO - 10.1212/WNL.0b013e3182840782

M3 - Article

VL - 80

SP - 810

EP - 813

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -