Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network

Sohyun Hwang, Seung Y. Rhee, Edward M. Marcotte, Insuk Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.

Original languageEnglish
Pages (from-to)1429-1442
Number of pages14
JournalNature Protocols
Volume6
Issue number9
DOIs
Publication statusPublished - 2011 Sep 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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