Abstract
AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
| Original language | English |
|---|---|
| Pages (from-to) | 1429-1442 |
| Number of pages | 14 |
| Journal | Nature Protocols |
| Volume | 6 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2011 Sep 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network. / Hwang, Sohyun; Rhee, Seung Y.; Marcotte, Edward M.; Lee, Insuk.
In: Nature Protocols, Vol. 6, No. 9, 01.09.2011, p. 1429-1442.Research output: Contribution to journal › Article
TY - JOUR
T1 - Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network
AU - Hwang, Sohyun
AU - Rhee, Seung Y.
AU - Marcotte, Edward M.
AU - Lee, Insuk
PY - 2011/9/1
Y1 - 2011/9/1
N2 - AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
AB - AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
UR - http://www.scopus.com/inward/record.url?scp=80052394788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052394788&partnerID=8YFLogxK
U2 - 10.1038/nprot.2011.372
DO - 10.1038/nprot.2011.372
M3 - Article
C2 - 21886106
AN - SCOPUS:80052394788
VL - 6
SP - 1429
EP - 1442
JO - Nature Protocols
JF - Nature Protocols
SN - 1754-2189
IS - 9
ER -