Systemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma

Jihei Sara Lee, Hyoung Won Bae, Sungeun Park, Chan Yun Kim, Sang Yeop Lee

Research output: Contribution to journalArticlepeer-review


PURPOSE. The purpose was to identify association between systemic arterial stiffness predicted by brachial-ankle pulse wave velocity (PWV) and initial location of structural progression in early open-angle glaucoma. METHODS. Patients with early open-angle glaucoma who underwent PWV measurements were subjected to a retrospective review of medical records. A total of 160 eyes of 160 patients were subjected to analyses. Patients were categorized into three PWV groups. Structural progression was determined using event-based analysis of the Guided Progression Analysis software of Cirrus optical coherence tomography. RESULTS. Thirty-eight patients had a PWV of 1400 cm/s or less on both the left and right sides (low PWV, 39.5% females, 53.9 ± 8.8 years old), and 46 patients showed a PWV of 1800 cm/s or more on either side (high PWV; 54.3% females, 71.3 ± 5.8 years old). The rest of the patients had an intermediate PWV (n = 76, 50.0% females, 59.8 ± 8.6 years old). Among patients who showed progression in 69.3 ± 41.5 months, macular ganglion cell-inner plexiform layer (mGCIPL) loss preceded peripapillary retinal nerve fiber layer (ppRNFL) loss in 86.7% of high PWV group (n = 15, 60.0% females, 70.0 ± 6.0 years old) in comparison with 26.7% of the low PWV group (P = 0.002). The PWV was significantly higher in patients whose structural progression was first observed at mGCIPL (1744.1 ± 347.7 cm/s) than patients whose initial location was ppRNFL (1452.0 ± 201.0 cm/s; P = 0.012). A high PWV was associated with increased likelihood of structural progression at mGCIPL (odds ratio, 7.484; 95% confidence interval, 1.212-49.196; P = 0.030) among patients who showed progression. CONCLUSIONS. PWV is a significant predictor of the location of structural progression in open-angle glaucoma. Vascular insufficiency may be an important aspect in the pathogenesis of glaucoma.

Original languageEnglish
Article number2778711
JournalInvestigative Ophthalmology and Visual Science
Issue number3
Publication statusPublished - 2022 Mar

Bibliographical note

Funding Information:
Overall responsibility: J.S. Lee, H.W. Bae, S. Park, C.Y. Kim, S.Y. Lee Supported by a faculty research grant of Yonsei University College of Medicine (6-2018-0155) and a research grant from Yongin Severance Hospital, Yonsei University College of Medicine (9-2020-0089).

Publisher Copyright:
© 2022 The Authors.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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