Systemic hypertension as a risk factor for open-angle glaucoma: A meta-analysis of population-based studies

Hyoung Won Bae, Naeun Lee, Hye Sun Lee, Samin Hong, Gong Je Seong, Chan Yun Kim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Conclusions: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.

Results: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for hightension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.

Background/Aims: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.

Methods:A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.

Original languageEnglish
Article numbere108226
JournalPloS one
Volume9
Issue number9
DOIs
Publication statusPublished - 2014 Sep 25

Fingerprint

glaucoma
Open Angle Glaucoma
meta-analysis
hypertension
Meta-Analysis
risk factors
Odds Ratio
Hypertension
Publication Bias
odds ratio
Glaucoma
Population
Low Tension Glaucoma
PubMed
Epidemiologic Studies
Confidence Intervals
epidemiological studies
confidence interval
testing

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Bae, Hyoung Won ; Lee, Naeun ; Lee, Hye Sun ; Hong, Samin ; Seong, Gong Je ; Kim, Chan Yun. / Systemic hypertension as a risk factor for open-angle glaucoma : A meta-analysis of population-based studies. In: PloS one. 2014 ; Vol. 9, No. 9.
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Systemic hypertension as a risk factor for open-angle glaucoma : A meta-analysis of population-based studies. / Bae, Hyoung Won; Lee, Naeun; Lee, Hye Sun; Hong, Samin; Seong, Gong Je; Kim, Chan Yun.

In: PloS one, Vol. 9, No. 9, e108226, 25.09.2014.

Research output: Contribution to journalArticle

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