Abstract
Conclusions: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.
Results: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for hightension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.
Background/Aims: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.
Methods:A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.
| Original language | English |
|---|---|
| Article number | e108226 |
| Journal | PloS one |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2014 Sep 25 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
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Systemic hypertension as a risk factor for open-angle glaucoma : A meta-analysis of population-based studies. / Bae, Hyoung Won; Lee, Naeun; Lee, Hye Sun; Hong, Samin; Seong, Gong Je; Kim, Chan Yun.
In: PloS one, Vol. 9, No. 9, e108226, 25.09.2014.Research output: Contribution to journal › Article
TY - JOUR
T1 - Systemic hypertension as a risk factor for open-angle glaucoma
T2 - A meta-analysis of population-based studies
AU - Bae, Hyoung Won
AU - Lee, Naeun
AU - Lee, Hye Sun
AU - Hong, Samin
AU - Seong, Gong Je
AU - Kim, Chan Yun
PY - 2014/9/25
Y1 - 2014/9/25
N2 - Conclusions: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.Results: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for hightension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.Background/Aims: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.Methods:A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.
AB - Conclusions: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.Results: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for hightension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis.Background/Aims: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies.Methods:A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test.
UR - http://www.scopus.com/inward/record.url?scp=84907588739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907588739&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0108226
DO - 10.1371/journal.pone.0108226
M3 - Article
C2 - 25254373
AN - SCOPUS:84907588739
VL - 9
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e108226
ER -