T 1 and T 2 dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials

Tae Hyun Shin, Jin Sil Choi, Seokhwan Yun, Il Sun Kim, Ho Taek Song, Youngmee Kim, Kook In Park, Jinwoo Cheon

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.

Original languageEnglish
Pages (from-to)3393-3401
Number of pages9
JournalACS Nano
Volume8
Issue number4
DOIs
Publication statusPublished - 2014 Apr 22

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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    Shin, T. H., Choi, J. S., Yun, S., Kim, I. S., Song, H. T., Kim, Y., Park, K. I., & Cheon, J. (2014). T 1 and T 2 dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials. ACS Nano, 8(4), 3393-3401. https://doi.org/10.1021/nn405977t