T-type Ca2+ channels as therapeutic targets in the nervous system

Hee Sup Shin, Eun Ji Cheong, Soonwook Choi, Jungryun Lee, Heung Sik Na

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated by a weak depolarization near the resting membrane potential once deinactivated by hyperpolarization, and therefore can regulate the excitability and electroresponsiveness of neurons under physiological conditions near resting states. Recently, the molecular diversity and functional multiplicity of T-type channels have been demonstrated through molecular genetic studies coupled with physiological and behavioral analysis. Understanding the functional consequences of modulation of each subtype of these channels in vivo could point to the right direction for developing therapeutic tools for relevant diseases.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume8
Issue number1
DOIs
Publication statusPublished - 2008 Feb 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this