Tailoring of microbes for the production of high value plant-derived compounds: From pathway engineering to fermentative production

Aravind Madhavan, Karthika Bahuleyan Arun, Raveendran Sindhu, Parameswaran Binod, Sang Hyoun Kim, Ashok Pandey

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Plant natural products have been an attracting platform for the isolation of various active drugs and other bioactives. However large-scale extraction of these compounds is affected by the difficulty in mass cultivation of these plants and absence of strategies for successful extraction. Even though, synthesis by chemical method is an alternative method; it is less efficient as their chemical structure is highly complex which involve enantio-selectivity. Thus an alternate bio-system for heterologous production of plant natural products using microbes has emerged. Advent of various omics, synthetic and metabolic engineering strategies revolutionised the field of heterologous plant metabolite production. In this context, various engineering methods taken to synthesise plant natural products are described with an additional focus to fermentation strategies.

Original languageEnglish
Article number140262
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1867
Issue number11
DOIs
Publication statusPublished - 2019 Nov

Bibliographical note

Funding Information:
Aravind Madhavan and Arun K. B acknowledge DST-SERB for providing NPDF . Raveendran Sindhu acknowledges Department of Science and Technology for sanctioning a project under DST WOS-B scheme.

Publisher Copyright:
© 2019 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

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