Target achievement with maximal statin-based lipid-lowering therapy in Korean patients with familial hypercholesterolemia: A study supported by the Korean Society of Lipid and Atherosclerosis

Jaewon Oh, Chan Joo Lee, Doo Il Kim, Moo Yong Rhee, Byoung Kwon Lee, Youngkeun Ahn, Byung Ryul Cho, Jeong Taek Woo, Seung Ho Hur, Jin Ok Jeong, Yangsoo Jang, Sang Hak Lee

Research output: Contribution to journalArticle

Abstract

Background: Data on treatment results of lipid-lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients. Hypothesis: We sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin-based LLT. Methods: We enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low-density lipoprotein cholesterol (LDL-C) target of 100 mg/dL. The primary evaluation point was the achievement rate of the LDL-C targets at 12 months: LDL-C < 100 mg/dL and ≥50% LDL-C reduction. The associations between clinical variables and target achievement were also analyzed. Results: At 12 months, 58% of patients were receiving high-intensity regimens, whereas 46% were receiving combination therapy. The mean pre- and post-treatment LDL-C levels were 229 and 118 mg/dL, respectively. Twenty-eight percent of patients achieved LDL-C < 100 mg/dL, and 47% achieved ≥50% LDL-C reduction. Pretreatment LDL-C and high-intensity regimens indicated a negative tendency toward the attainment of LDL-C < 100 mg/dL. Conversely, pretreatment LDL-C and diabetes mellitus were positively associated with a higher rate of ≥50% LDL-C reduction. Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50% LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.

Original languageEnglish
Pages (from-to)1291-1296
Number of pages6
JournalClinical Cardiology
Volume40
Issue number12
DOIs
Publication statusPublished - 2017 Dec

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
LDL Cholesterol
Atherosclerosis
Lipids
Therapeutics
Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Oh, Jaewon ; Lee, Chan Joo ; Kim, Doo Il ; Rhee, Moo Yong ; Lee, Byoung Kwon ; Ahn, Youngkeun ; Cho, Byung Ryul ; Woo, Jeong Taek ; Hur, Seung Ho ; Jeong, Jin Ok ; Jang, Yangsoo ; Lee, Sang Hak. / Target achievement with maximal statin-based lipid-lowering therapy in Korean patients with familial hypercholesterolemia : A study supported by the Korean Society of Lipid and Atherosclerosis. In: Clinical Cardiology. 2017 ; Vol. 40, No. 12. pp. 1291-1296.
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title = "Target achievement with maximal statin-based lipid-lowering therapy in Korean patients with familial hypercholesterolemia: A study supported by the Korean Society of Lipid and Atherosclerosis",
abstract = "Background: Data on treatment results of lipid-lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients. Hypothesis: We sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin-based LLT. Methods: We enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low-density lipoprotein cholesterol (LDL-C) target of 100 mg/dL. The primary evaluation point was the achievement rate of the LDL-C targets at 12 months: LDL-C < 100 mg/dL and ≥50{\%} LDL-C reduction. The associations between clinical variables and target achievement were also analyzed. Results: At 12 months, 58{\%} of patients were receiving high-intensity regimens, whereas 46{\%} were receiving combination therapy. The mean pre- and post-treatment LDL-C levels were 229 and 118 mg/dL, respectively. Twenty-eight percent of patients achieved LDL-C < 100 mg/dL, and 47{\%} achieved ≥50{\%} LDL-C reduction. Pretreatment LDL-C and high-intensity regimens indicated a negative tendency toward the attainment of LDL-C < 100 mg/dL. Conversely, pretreatment LDL-C and diabetes mellitus were positively associated with a higher rate of ≥50{\%} LDL-C reduction. Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50{\%} LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.",
author = "Jaewon Oh and Lee, {Chan Joo} and Kim, {Doo Il} and Rhee, {Moo Yong} and Lee, {Byoung Kwon} and Youngkeun Ahn and Cho, {Byung Ryul} and Woo, {Jeong Taek} and Hur, {Seung Ho} and Jeong, {Jin Ok} and Yangsoo Jang and Lee, {Sang Hak}",
year = "2017",
month = "12",
doi = "10.1002/clc.22826",
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pages = "1291--1296",
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Target achievement with maximal statin-based lipid-lowering therapy in Korean patients with familial hypercholesterolemia : A study supported by the Korean Society of Lipid and Atherosclerosis. / Oh, Jaewon; Lee, Chan Joo; Kim, Doo Il; Rhee, Moo Yong; Lee, Byoung Kwon; Ahn, Youngkeun; Cho, Byung Ryul; Woo, Jeong Taek; Hur, Seung Ho; Jeong, Jin Ok; Jang, Yangsoo; Lee, Sang Hak.

In: Clinical Cardiology, Vol. 40, No. 12, 12.2017, p. 1291-1296.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Target achievement with maximal statin-based lipid-lowering therapy in Korean patients with familial hypercholesterolemia

T2 - A study supported by the Korean Society of Lipid and Atherosclerosis

AU - Oh, Jaewon

AU - Lee, Chan Joo

AU - Kim, Doo Il

AU - Rhee, Moo Yong

AU - Lee, Byoung Kwon

AU - Ahn, Youngkeun

AU - Cho, Byung Ryul

AU - Woo, Jeong Taek

AU - Hur, Seung Ho

AU - Jeong, Jin Ok

AU - Jang, Yangsoo

AU - Lee, Sang Hak

PY - 2017/12

Y1 - 2017/12

N2 - Background: Data on treatment results of lipid-lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients. Hypothesis: We sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin-based LLT. Methods: We enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low-density lipoprotein cholesterol (LDL-C) target of 100 mg/dL. The primary evaluation point was the achievement rate of the LDL-C targets at 12 months: LDL-C < 100 mg/dL and ≥50% LDL-C reduction. The associations between clinical variables and target achievement were also analyzed. Results: At 12 months, 58% of patients were receiving high-intensity regimens, whereas 46% were receiving combination therapy. The mean pre- and post-treatment LDL-C levels were 229 and 118 mg/dL, respectively. Twenty-eight percent of patients achieved LDL-C < 100 mg/dL, and 47% achieved ≥50% LDL-C reduction. Pretreatment LDL-C and high-intensity regimens indicated a negative tendency toward the attainment of LDL-C < 100 mg/dL. Conversely, pretreatment LDL-C and diabetes mellitus were positively associated with a higher rate of ≥50% LDL-C reduction. Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50% LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.

AB - Background: Data on treatment results of lipid-lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients. Hypothesis: We sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin-based LLT. Methods: We enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low-density lipoprotein cholesterol (LDL-C) target of 100 mg/dL. The primary evaluation point was the achievement rate of the LDL-C targets at 12 months: LDL-C < 100 mg/dL and ≥50% LDL-C reduction. The associations between clinical variables and target achievement were also analyzed. Results: At 12 months, 58% of patients were receiving high-intensity regimens, whereas 46% were receiving combination therapy. The mean pre- and post-treatment LDL-C levels were 229 and 118 mg/dL, respectively. Twenty-eight percent of patients achieved LDL-C < 100 mg/dL, and 47% achieved ≥50% LDL-C reduction. Pretreatment LDL-C and high-intensity regimens indicated a negative tendency toward the attainment of LDL-C < 100 mg/dL. Conversely, pretreatment LDL-C and diabetes mellitus were positively associated with a higher rate of ≥50% LDL-C reduction. Conclusions: The target achievement of LDL-C < 100 mg/dL was low, and 50% LDL-C reduction was moderately achieved in Korean patients with FH receiving maximal statin-based LLT. Pretreatment LDL-C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.

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U2 - 10.1002/clc.22826

DO - 10.1002/clc.22826

M3 - Article

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SP - 1291

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