Target-localized nanograting-based surface plasmon resonance detection toward label-free molecular biosensing

Kyungjae Ma, Dong Jun Kim, Kyujung Kim, Seyoung Moon, Donghyun Kim

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We explore the sensitivity enhancement of label-free detection based on localized surface plasmon resonance using surface-relief nanograting structures. A nanograting structure was modeled, so that target molecular interactions are localized in hot spots of the near fields. The nanograting structure was optimized numerically for the highest enhancement of sensitivity with hybridization between complementary strands of DNA as the model target interaction. Experimentally, angled evaporation was performed to fabricate the target-localized nanograting samples. Measured data confirm the numerical results that sensitivity enhancement by an order of magnitude may be feasible on a per-unit-volume basis through target localization.

Original languageEnglish
Article number5382525
Pages (from-to)1004-1014
Number of pages11
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume16
Issue number4
DOIs
Publication statusPublished - 2010 Jul 1

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Molecular interactions
Surface plasmon resonance
surface plasmon resonance
Labels
Evaporation
DNA
augmentation
sensitivity
molecular interactions
strands
near fields
deoxyribonucleic acid
evaporation
interactions

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Cite this

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abstract = "We explore the sensitivity enhancement of label-free detection based on localized surface plasmon resonance using surface-relief nanograting structures. A nanograting structure was modeled, so that target molecular interactions are localized in hot spots of the near fields. The nanograting structure was optimized numerically for the highest enhancement of sensitivity with hybridization between complementary strands of DNA as the model target interaction. Experimentally, angled evaporation was performed to fabricate the target-localized nanograting samples. Measured data confirm the numerical results that sensitivity enhancement by an order of magnitude may be feasible on a per-unit-volume basis through target localization.",
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Target-localized nanograting-based surface plasmon resonance detection toward label-free molecular biosensing. / Ma, Kyungjae; Kim, Dong Jun; Kim, Kyujung; Moon, Seyoung; Kim, Donghyun.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 16, No. 4, 5382525, 01.07.2010, p. 1004-1014.

Research output: Contribution to journalArticle

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