We explore the sensitivity enhancement of label-free detection based on localized surface plasmon resonance using surface-relief nanograting structures. A nanograting structure was modeled, so that target molecular interactions are localized in hot spots of the near fields. The nanograting structure was optimized numerically for the highest enhancement of sensitivity with hybridization between complementary strands of DNA as the model target interaction. Experimentally, angled evaporation was performed to fabricate the target-localized nanograting samples. Measured data confirm the numerical results that sensitivity enhancement by an order of magnitude may be feasible on a per-unit-volume basis through target localization.
|Number of pages||11|
|Journal||IEEE Journal on Selected Topics in Quantum Electronics|
|Publication status||Published - 2010 Jul|
Bibliographical noteFunding Information:
Manuscript received August 1, 2009; revised August 14, 2009 and September 17, 2009; accepted September 30, 2009. Date of publication January 15, 2010; date of current version August 6, 2010. This work was supported in part by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology under Grant R15-2004-024-00000-0 and Grant M10755020003-08N5502-00310, in part by the Korea Research Foundation (KRF) Grant funded by the Korean Government under Grant KRF-2008-331-D00389, in part by the Ministry of Knowledge Economy under Project “System IC 2010,” and in part by the Microelectromechanical Systems Research Center for National Defense under Grant 2009-MM-41-UD090024FD funded by the Defense Acquisition Program Administration.
All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering