Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Sun Mi Lee, Hyung Joon Kim, You Jung Ha, Young Nyun Park, Soo Kon Lee, Yong Beom Park, Kyung Hwa Yoo

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalACS Nano
Volume7
Issue number1
DOIs
Publication statusPublished - 2013 Jan 22

Fingerprint

arthritis
Methotrexate
Gold
gold
Nanoparticles
Infrared radiation
drugs
nanoparticles
Irradiation
Antirheumatic Agents
Collagen
Peptides
heat
dosage
irradiation
collagens
peptides
mice
delivery
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Lee, Sun Mi ; Kim, Hyung Joon ; Ha, You Jung ; Park, Young Nyun ; Lee, Soo Kon ; Park, Yong Beom ; Yoo, Kyung Hwa. / Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. In: ACS Nano. 2013 ; Vol. 7, No. 1. pp. 50-57.
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Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. / Lee, Sun Mi; Kim, Hyung Joon; Ha, You Jung; Park, Young Nyun; Lee, Soo Kon; Park, Yong Beom; Yoo, Kyung Hwa.

In: ACS Nano, Vol. 7, No. 1, 22.01.2013, p. 50-57.

Research output: Contribution to journalArticle

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