Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Sun Mi Lee; Hyung Joon Kim; You Jung Ha; Young Nyun Park; Soo Kon Lee; Yong Beom Park; Kyung Hwa Yoo

doi:10.1021/nn301215q

Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Sun Mi Lee, Hyung Joon Kim, You Jung Ha, Young Nyun Park, Soo Kon Lee, Yong Beom Park, Kyung Hwa Yoo

Research output: Contribution to journal › Article › peer-review

185 Citations (Scopus)

Abstract

We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	ACS Nano
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/nn301215q
Publication status	Published - 2013 Jan 22

All Science Journal Classification (ASJC) codes

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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abstract = "We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.",

author = "Lee, {Sun Mi} and Kim, {Hyung Joon} and Ha, {You Jung} and Park, {Young Nyun} and Lee, {Soo Kon} and Park, {Yong Beom} and Yoo, {Kyung Hwa}",

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AU - Lee, Soo Kon

AU - Park, Yong Beom

AU - Yoo, Kyung Hwa

PY - 2013/1/22

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Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

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