Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Myung Ryul Lee, Kyung Hwa Baek, Hui Juan Jin, Yong Gyu Jung, Injae Shin

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Double whammy: Effective and selective killing of E. coli cells containing a specific enzyme was achieved by using targeted enzyme-responsive drug carriers (see picture) that release free drugs in a stringently controlled manner. The carrier lowered the effective concentration of drug needed to kill the bacteria. The system could also be modified to deliver a combination of two drugs.

Original languageEnglish
Pages (from-to)1675-1678
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number13
DOIs
Publication statusPublished - 2004 Mar 19

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Drug Carriers
Drug Combinations
Enzymes
Pharmaceutical Preparations
Escherichia coli
Bacteria

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Lee, Myung Ryul ; Baek, Kyung Hwa ; Jin, Hui Juan ; Jung, Yong Gyu ; Shin, Injae. / Targeted enzyme-responsive drug carriers : Studies on the delivery of a combination of drugs. In: Angewandte Chemie - International Edition. 2004 ; Vol. 43, No. 13. pp. 1675-1678.
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Targeted enzyme-responsive drug carriers : Studies on the delivery of a combination of drugs. / Lee, Myung Ryul; Baek, Kyung Hwa; Jin, Hui Juan; Jung, Yong Gyu; Shin, Injae.

In: Angewandte Chemie - International Edition, Vol. 43, No. 13, 19.03.2004, p. 1675-1678.

Research output: Contribution to journalArticle

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