Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

Myung Ryul Lee, Kyung Hwa Baek, Hui Juan Jin, Yong Gyu Jung, Injae Shin

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Double whammy: Effective and selective killing of E. coli cells containing a specific enzyme was achieved by using targeted enzyme-responsive drug carriers (see picture) that release free drugs in a stringently controlled manner. The carrier lowered the effective concentration of drug needed to kill the bacteria. The system could also be modified to deliver a combination of two drugs.

Original languageEnglish
Pages (from-to)1675-1678
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number13
DOIs
Publication statusPublished - 2004 Mar 19

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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