Targeted nanoparticles for cancer therapy

Frank X. Gu; Rohit Karnik; Andrew Z. Wang; Frank Alexis; Etgar Levy-Nissenbaum; Seungpyo Hong; Robert S. Langer; Omid C. Farokhzad

doi:10.1016/S1748-0132(07)70083-X

Targeted nanoparticles for cancer therapy

Frank X. Gu, Rohit Karnik, Andrew Z. Wang, Frank Alexis, Etgar Levy-Nissenbaum, Seungpyo Hong, Robert S. Langer, Omid C. Farokhzad

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

435 Citations (Scopus)

Abstract

Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.

Original language	English
Pages (from-to)	14-21
Number of pages	8
Journal	Nano Today
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S1748-0132(07)70083-X
Publication status	Published - 2007 Jun

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering
Materials Science(all)
Pharmaceutical Science

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abstract = "Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.",

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AU - Hong, Seungpyo

AU - Langer, Robert S.

AU - Farokhzad, Omid C.

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AB - Over the past decade, there has been an increasing interest in using nanotechnology for cancer therapy. The development of smart targeted nanoparticles (NPs) that can deliver drugs at a sustained rate directly to cancer cells may provide better efficacy and lower toxicity for treating primary and advanced metastatic tumors. We highlight some of the promising classes of targeting molecules that are under development for the delivery of NPs. We also review the emerging technologies for the fabrication of targeted NPs using microfluidic devices.

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