Targeting Autophagy In Disease: Recent Advances In Drug Discovery

Dasol Kim, Hui Yun Hwang, Ho Jeong Kwon

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Introduction: Small molecules targeting autophagy have been highly implicated as new therapeutic agents to treat diseases of interest. With the increasing demand for autophagy-targeting drugs, this review attempts to provide an efficient strategy to explore major autophagy-based human disease interventions with newly explored mechanisms using small molecules and promising therapeutic approaches. Areas covered: Introduced in this review are direct links and applications among autophagy pathways, their modulators, and phenotypic diseases, along with recent approaches. Autophagy-related diseases, machinery, and compounds are introduced to guide the appropriate investigation of autophagy in the pharmaceutical industry. The authors then provide their expert perspectives on the subject. Expert opinion: The self-catabolic intracellular process autophagy occurs in organisms throughout their lifetime, supporting its critical role in organismal health across life stages. Because of the detrimental influence of dysfunctional cells to an organism and their etiology in numerous diseases, maintaining cellular quality control by recycling components through autophagy is essential to prevent health decline.

Original languageEnglish
Pages (from-to)1045-1064
Number of pages20
JournalExpert Opinion on Drug Discovery
Issue number9
Publication statusPublished - 2020 Sept 1

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea, funded by the Korean government (MSIP; 2015K1A1A2028365, 2015M3A9B6027818, 2016K2A9A1A03904900, 2018M3A9C4076477), the Brain Korea 21Plus Project in the Republic of Korea and ICONS (the Institute of Convergence Science), Yonsei University.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Drug Discovery


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