Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases

Hwa Jeong You, Jae Hyon Park, Helios Pareja-Galeano, Alejandro Lucia, Jae Il Shin

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.

Original languageEnglish
Pages (from-to)540-550
Number of pages11
JournalNeuroMolecular Medicine
Volume18
Issue number4
DOIs
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

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