Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis

Chulhyoung Lyoo, Hanna Cho, Jae Yong Choi, Mi Song Hwang, Sang Kyoon Hong, Yun Joong Kim, Young Hoon Ryu, Myung Sik Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied topographic distribution of tau and amyloid-β in a patient with variant Alzheimer's disease with spastic paraparesis (VarAD) by comparing AD patients. The proband developed progressive memory impairment, dysarthria, and spastic paraparesis at age 23. Heterozygous missense mutation (L166P) was found in exon 6 of presenilin-1 gene. The proband showed prominently increased amyloid binding in striatum and cerebellum and asymmetrical tau binding in the primary sensorimotor cortex contralateral to the side more affected by spasticity. We suspect that upper motor neuron dysfunctions may be attributed to excessive abnormal tau accumulation rather than amyloid-β in the primary motor cortex.

Original languageEnglish
Pages (from-to)671-675
Number of pages5
JournalJournal of Alzheimer's Disease
Volume51
Issue number3
DOIs
Publication statusPublished - 2016 Mar 30

Fingerprint

Spastic Paraparesis
Motor Cortex
Amyloid
Alzheimer Disease
Presenilin-1
Dysarthria
Motor Neurons
Missense Mutation
Cerebellum
Exons
Genes
Primary amyloidosis
Sensorimotor Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Lyoo, Chulhyoung ; Cho, Hanna ; Choi, Jae Yong ; Hwang, Mi Song ; Hong, Sang Kyoon ; Kim, Yun Joong ; Ryu, Young Hoon ; Lee, Myung Sik. / Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. In: Journal of Alzheimer's Disease. 2016 ; Vol. 51, No. 3. pp. 671-675.
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Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. / Lyoo, Chulhyoung; Cho, Hanna; Choi, Jae Yong; Hwang, Mi Song; Hong, Sang Kyoon; Kim, Yun Joong; Ryu, Young Hoon; Lee, Myung Sik.

In: Journal of Alzheimer's Disease, Vol. 51, No. 3, 30.03.2016, p. 671-675.

Research output: Contribution to journalArticle

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