Taurine alleviates the progression of diabetic nephropathy in type 2 diabetic rat model

Jang Hyun Koh, Eun Soo Lee, Miri Hyun, Hong Min Kim, Yoon Jung Choi, Eun Young Lee, Dhananjay Yadav, Choon Hee Chung

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19 Citations (Scopus)

Abstract

The overexpression of vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of diabetic nephropathy. In this study, the protective effects of taurine on diabetic nephropathy along with its underlying mechanism were investigated. Experimental animals were divided into three groups: LETO rats as normal group (n = 10), OLETF rats as diabetic control group (n = 10), and OLETF rats treated with taurine group (n = 10). We treated taurine (200 mg/kg/day) for 20 weeks and treated high glucose (HG, 30 mM) with or without taurine (30 mM) in mouse cultured podocyte. After taurine treatment, blood glucose level was decreased and insulin secretion was increased. Taurine significantly reduced albuminuria and ACR. Also it decreased glomerular volume, GBM thickness and increased open slit pore density through decreased VEGF and increased nephrin mRNA expressions in renal cortex. The antioxidant effects of taurine were confirmed by the reduction of urine MDA in taurine treated diabetic group. Also reactive oxygen species (ROS) levels were decreased in HG condition with taurine treated podocytes compared to without taurine. These results indicate that taurine lowers glucose level via increased insulin secretion and ameliorates the progression of diabetic nephropathy through antifibrotic and antioxidant effects in type 2 diabetes rat model.

Original languageEnglish
Article number397307
JournalInternational Journal of Endocrinology
Volume2014
DOIs
Publication statusPublished - 2014 Mar 28

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Taurine
Diabetic Nephropathies
Inbred OLETF Rats
Podocytes
Vascular Endothelial Growth Factor A
Antioxidants
Insulin
Glucose
Albuminuria
Type 2 Diabetes Mellitus
Blood Glucose
Reactive Oxygen Species
Urine
Kidney

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Koh, Jang Hyun ; Lee, Eun Soo ; Hyun, Miri ; Kim, Hong Min ; Choi, Yoon Jung ; Lee, Eun Young ; Yadav, Dhananjay ; Chung, Choon Hee. / Taurine alleviates the progression of diabetic nephropathy in type 2 diabetic rat model. In: International Journal of Endocrinology. 2014 ; Vol. 2014.
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Taurine alleviates the progression of diabetic nephropathy in type 2 diabetic rat model. / Koh, Jang Hyun; Lee, Eun Soo; Hyun, Miri; Kim, Hong Min; Choi, Yoon Jung; Lee, Eun Young; Yadav, Dhananjay; Chung, Choon Hee.

In: International Journal of Endocrinology, Vol. 2014, 397307, 28.03.2014.

Research output: Contribution to journalArticle

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