Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

Hye Yun Kim, Hyunjin V. Kim, Jin H. Yoon, Bo Ram Kang, Soo Min Cho, Sejin Lee, Ji Yoon Kim, Joo Won Kim, Yakdol Cho, Jiwan Woo, Young Soo Kim

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/ PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages.

Original languageEnglish
Article number7467
JournalScientific reports
Publication statusPublished - 2014 Dec 12

Bibliographical note

Funding Information:
This work was supported by KIST Institutional Programs (Open Research 2E24582 and Flagship 2E25023), KHIDI (H14C04660000), UST Research Internship Program and MIT International Science & Technology Initiatives (MISTI). We appreciate Dr Jun-Seok Lee and Young-Hwa Yoo for the Y-maze analysis program.

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this