Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

Hye Yun Kim, Hyunjin V. Kim, Jin H. Yoon, Bo Ram Kang, Soo Min Cho, Sejin Lee, Ji Yoon Kim, Joo Won Kim, Yakdol Cho, Jiwan Woo, YoungSoo Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/ PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages.

Original languageEnglish
Article number7467
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Dec 12

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Taurine
Drinking Water
Alzheimer Disease
Learning
Transgenic Mice
Drug Approval
United States Food and Drug Administration
Nervous System Diseases
Dementia
Clinical Trials
Amino Acids
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, Hye Yun ; Kim, Hyunjin V. ; Yoon, Jin H. ; Kang, Bo Ram ; Cho, Soo Min ; Lee, Sejin ; Kim, Ji Yoon ; Kim, Joo Won ; Cho, Yakdol ; Woo, Jiwan ; Kim, YoungSoo. / Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease. In: Scientific reports. 2014 ; Vol. 4.
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Kim, HY, Kim, HV, Yoon, JH, Kang, BR, Cho, SM, Lee, S, Kim, JY, Kim, JW, Cho, Y, Woo, J & Kim, Y 2014, 'Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease', Scientific reports, vol. 4, 7467. https://doi.org/10.1038/srep07467

Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease. / Kim, Hye Yun; Kim, Hyunjin V.; Yoon, Jin H.; Kang, Bo Ram; Cho, Soo Min; Lee, Sejin; Kim, Ji Yoon; Kim, Joo Won; Cho, Yakdol; Woo, Jiwan; Kim, YoungSoo.

In: Scientific reports, Vol. 4, 7467, 12.12.2014.

Research output: Contribution to journalArticle

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