Telomerase reverse transcriptase contains a BH3-like motif and interacts with BCL-2 family members

Young Jin, Long You, Hye Jeong Kim, Han Woong Lee

Research output: Contribution to journalArticle

Abstract

Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and anti-apoptotic proteins. Although the detailed mechanisms underlying the hTERT BH3-like motif functions and interactions between hTERT and BCL-2 family proteins have not been elucidated, this work proposes a possible connection between hTERT and BCL-2 family members and reconsiders the role of the BH3-like motif as an interaction motif.

Original languageEnglish
Pages (from-to)684-694
Number of pages11
JournalMolecules and cells
Volume41
Issue number7
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Telomerase
Proteins
Apoptosis
human TERT protein
Apoptosis Regulatory Proteins
Telomere
Up-Regulation
Peptides

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

@article{349d7dee8e2248719c509f1ca609a324,
title = "Telomerase reverse transcriptase contains a BH3-like motif and interacts with BCL-2 family members",
abstract = "Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and anti-apoptotic proteins. Although the detailed mechanisms underlying the hTERT BH3-like motif functions and interactions between hTERT and BCL-2 family proteins have not been elucidated, this work proposes a possible connection between hTERT and BCL-2 family members and reconsiders the role of the BH3-like motif as an interaction motif.",
author = "Young Jin and Long You and Kim, {Hye Jeong} and Lee, {Han Woong}",
year = "2018",
month = "1",
day = "1",
doi = "10.14348/molcells.2018.0206",
language = "English",
volume = "41",
pages = "684--694",
journal = "Molecules and Cells",
issn = "1016-8478",
publisher = "Korean Society for Molecular and Cellular Biology",
number = "7",

}

Telomerase reverse transcriptase contains a BH3-like motif and interacts with BCL-2 family members. / Jin, Young; You, Long; Kim, Hye Jeong; Lee, Han Woong.

In: Molecules and cells, Vol. 41, No. 7, 01.01.2018, p. 684-694.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Telomerase reverse transcriptase contains a BH3-like motif and interacts with BCL-2 family members

AU - Jin, Young

AU - You, Long

AU - Kim, Hye Jeong

AU - Lee, Han Woong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and anti-apoptotic proteins. Although the detailed mechanisms underlying the hTERT BH3-like motif functions and interactions between hTERT and BCL-2 family proteins have not been elucidated, this work proposes a possible connection between hTERT and BCL-2 family members and reconsiders the role of the BH3-like motif as an interaction motif.

AB - Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a functional link between hTERT and the mitochondrial pathway of apoptosis. Additionally, we propose that hTERT can be categorized into the atypical BH3-only proteins that promote cellular survival, possibly due to the non-canonical interaction between hTERT and anti-apoptotic proteins. Although the detailed mechanisms underlying the hTERT BH3-like motif functions and interactions between hTERT and BCL-2 family proteins have not been elucidated, this work proposes a possible connection between hTERT and BCL-2 family members and reconsiders the role of the BH3-like motif as an interaction motif.

UR - http://www.scopus.com/inward/record.url?scp=85056286420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056286420&partnerID=8YFLogxK

U2 - 10.14348/molcells.2018.0206

DO - 10.14348/molcells.2018.0206

M3 - Article

C2 - 29937479

AN - SCOPUS:85056286420

VL - 41

SP - 684

EP - 694

JO - Molecules and Cells

JF - Molecules and Cells

SN - 1016-8478

IS - 7

ER -