Abstract
The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-dcficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 164-175 |
| Number of pages | 12 |
| Journal | Molecules and Cells |
| Volume | 15 |
| Issue number | 2 |
| Publication status | Published - 2003 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Cell Biology
- Genetics
- Molecular Biology
Cite this
}
Telomeres and telomerase in aging, regeneration and cancer. / Djojosubroto, Meta Wulandari; Choi, Yoon Sik; Lee, Han Woong; Rudolph, Karl Lenhard.
In: Molecules and Cells, Vol. 15, No. 2, 01.04.2003, p. 164-175.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Telomeres and telomerase in aging, regeneration and cancer
AU - Djojosubroto, Meta Wulandari
AU - Choi, Yoon Sik
AU - Lee, Han Woong
AU - Rudolph, Karl Lenhard
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-dcficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis.
AB - The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-dcficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037928721&partnerID=8YFLogxK
M3 - Short survey
C2 - 12803478
AN - SCOPUS:0037928721
VL - 15
SP - 164
EP - 175
JO - Molecules and Cells
JF - Molecules and Cells
SN - 1016-8478
IS - 2
ER -