Terbinafine inhibits gap junctional intercellular communication

Ju Yeun Lee, Sei Mee Yoon, Eun Ju Choi, Jinu Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Terbinafine is an antifungal agent that selectively inhibits fungal sterol synthesis by blocking squalene epoxidase. We evaluated the effect of terbinafine on gap junctional intercellular communication (GJIC). Fluorescence recovery after photobleaching (FRAP) and I-YFP GJIC assays revealed that terbinafine inhibits GJIC in a reversible and dose-dependent manner in FRT-Cx43 and LN215 cells. Treatment with terbinafine did not affect Cx43 phosphorylation status or intracellular Ca2+ concentration, well-known action mechanisms of various GJIC blockers. While a structurally related chemical, naftifine, attenuated GJIC, epigallocatechin gallate, another potent squalene epoxidase inhibitor with a different structure, did not. These results suggest that terbinafine inhibits GJIC with a so far unknown mechanism of action.

Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalToxicology and Applied Pharmacology
Volume307
DOIs
Publication statusPublished - 2016 Sep 15

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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