Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants

Re Mee Doh, Hye Jeong Park, Yumie Rhee, Hyun Sil Kim, Jisun Huh, Wonse Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This report describes a case of teriparatide (TPTD) therapy for bisphosphonate (BP)-related osteonecrosis of the jaw induced after implant placement. A 75-year-old woman taking oral BP was referred with uncontrolled osteonecrosis of the mandible related to the implant placement. With conservative treatment, BP was suspended and daily subcutaneous injections of 20 m/d TPTD were started. After 4 months of the therapy, fixture removal and sequestrectomy were performed. Histological analysis revealed necrotic lamellar bone and empty osteocytic lacunae. In contrast, multiple irregular reversal lines of the lamellar bone and active osteoblasts were noted adjacent to the lesion. There was a significant increase in serum C-terminal telopeptide cross-link of type 1 collagen and serum osteocalcin after commencement of the therapy. After 7 months off therapy, the serum levels of the 2 markers remained at a high level compared with the baseline.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalImplant dentistry
Volume24
Issue number2
DOIs
Publication statusPublished - 2015 Apr 4

Fingerprint

Bisphosphonate-Associated Osteonecrosis of the Jaw
Teriparatide
Dental Implants
Diphosphonates
Serum
Bone and Bones
Osteonecrosis
Osteocalcin
Subcutaneous Injections
Therapeutics
Collagen Type I
Osteoblasts
Mandible

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

Doh, Re Mee ; Park, Hye Jeong ; Rhee, Yumie ; Kim, Hyun Sil ; Huh, Jisun ; Park, Wonse. / Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants. In: Implant dentistry. 2015 ; Vol. 24, No. 2. pp. 222-226.
@article{21e7a77db3cb4994b44876c2c1f29d96,
title = "Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants",
abstract = "This report describes a case of teriparatide (TPTD) therapy for bisphosphonate (BP)-related osteonecrosis of the jaw induced after implant placement. A 75-year-old woman taking oral BP was referred with uncontrolled osteonecrosis of the mandible related to the implant placement. With conservative treatment, BP was suspended and daily subcutaneous injections of 20 m/d TPTD were started. After 4 months of the therapy, fixture removal and sequestrectomy were performed. Histological analysis revealed necrotic lamellar bone and empty osteocytic lacunae. In contrast, multiple irregular reversal lines of the lamellar bone and active osteoblasts were noted adjacent to the lesion. There was a significant increase in serum C-terminal telopeptide cross-link of type 1 collagen and serum osteocalcin after commencement of the therapy. After 7 months off therapy, the serum levels of the 2 markers remained at a high level compared with the baseline.",
author = "Doh, {Re Mee} and Park, {Hye Jeong} and Yumie Rhee and Kim, {Hyun Sil} and Jisun Huh and Wonse Park",
year = "2015",
month = "4",
day = "4",
doi = "10.1097/ID.0000000000000232",
language = "English",
volume = "24",
pages = "222--226",
journal = "Implant Dentistry",
issn = "1056-6163",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants. / Doh, Re Mee; Park, Hye Jeong; Rhee, Yumie; Kim, Hyun Sil; Huh, Jisun; Park, Wonse.

In: Implant dentistry, Vol. 24, No. 2, 04.04.2015, p. 222-226.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants

AU - Doh, Re Mee

AU - Park, Hye Jeong

AU - Rhee, Yumie

AU - Kim, Hyun Sil

AU - Huh, Jisun

AU - Park, Wonse

PY - 2015/4/4

Y1 - 2015/4/4

N2 - This report describes a case of teriparatide (TPTD) therapy for bisphosphonate (BP)-related osteonecrosis of the jaw induced after implant placement. A 75-year-old woman taking oral BP was referred with uncontrolled osteonecrosis of the mandible related to the implant placement. With conservative treatment, BP was suspended and daily subcutaneous injections of 20 m/d TPTD were started. After 4 months of the therapy, fixture removal and sequestrectomy were performed. Histological analysis revealed necrotic lamellar bone and empty osteocytic lacunae. In contrast, multiple irregular reversal lines of the lamellar bone and active osteoblasts were noted adjacent to the lesion. There was a significant increase in serum C-terminal telopeptide cross-link of type 1 collagen and serum osteocalcin after commencement of the therapy. After 7 months off therapy, the serum levels of the 2 markers remained at a high level compared with the baseline.

AB - This report describes a case of teriparatide (TPTD) therapy for bisphosphonate (BP)-related osteonecrosis of the jaw induced after implant placement. A 75-year-old woman taking oral BP was referred with uncontrolled osteonecrosis of the mandible related to the implant placement. With conservative treatment, BP was suspended and daily subcutaneous injections of 20 m/d TPTD were started. After 4 months of the therapy, fixture removal and sequestrectomy were performed. Histological analysis revealed necrotic lamellar bone and empty osteocytic lacunae. In contrast, multiple irregular reversal lines of the lamellar bone and active osteoblasts were noted adjacent to the lesion. There was a significant increase in serum C-terminal telopeptide cross-link of type 1 collagen and serum osteocalcin after commencement of the therapy. After 7 months off therapy, the serum levels of the 2 markers remained at a high level compared with the baseline.

UR - http://www.scopus.com/inward/record.url?scp=84926192269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926192269&partnerID=8YFLogxK

U2 - 10.1097/ID.0000000000000232

DO - 10.1097/ID.0000000000000232

M3 - Article

C2 - 25734949

AN - SCOPUS:84926192269

VL - 24

SP - 222

EP - 226

JO - Implant Dentistry

JF - Implant Dentistry

SN - 1056-6163

IS - 2

ER -