Tetrasomy 8 in a patient with acute monoblastic Leukemia

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung A. Lee, Sang Guk Lee, June Won Cheong, Jong Rak Choi

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Abstract

Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.

Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalKorean Journal of Laboratory Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - 2008 Dec 1

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All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kim, J., Park, T. S., Song, J., Lee, K. A., Lee, S. G., Cheong, J. W., & Choi, J. R. (2008). Tetrasomy 8 in a patient with acute monoblastic Leukemia. Korean Journal of Laboratory Medicine, 28(4), 262-266. https://doi.org/10.3343/kjlm.2008.28.4.262