Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing

Eunji Cheong, Chanki Kim, B. Jiwon Choi, Minjeong Sun, Hee Sup Shin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ryanodine receptors (RyRs) are highly conductive intracellular Ca 2+ release channels which are widely expressed in the CNS. They rapidly increase the intracellular Ca2+ concentrations in neuronal cells in response to Ca2+ influx through voltage-gated Ca 2+ channels. A previous study reported that RyRs were expressed in thalamocortical (TC) neurons, but their physiological function has remained elusive. Here, we show that the activation of RyRs in TC neurons in mice decreases their tonic firing rate while blocking them induces the opposite response. Furthermore, activation of RyRs in ventroposteriomedial/ ventroposteriolateral nuclei reduces the behavioral responses to inflammatory pain and blocking them increases the responses. This study highlights the importance of the intracellular Ca2+ release via RyRs in controlling the excitability of TC neurons and in inflammatory pain signal processing in the thalamus.

Original languageEnglish
Pages (from-to)1213-1218
Number of pages6
JournalJournal of Neuroscience
Volume31
Issue number4
DOIs
Publication statusPublished - 2011 Jan 26

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Ryanodine Receptor Calcium Release Channel
Neurons
Pain
Thalamus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing",
abstract = "Ryanodine receptors (RyRs) are highly conductive intracellular Ca 2+ release channels which are widely expressed in the CNS. They rapidly increase the intracellular Ca2+ concentrations in neuronal cells in response to Ca2+ influx through voltage-gated Ca 2+ channels. A previous study reported that RyRs were expressed in thalamocortical (TC) neurons, but their physiological function has remained elusive. Here, we show that the activation of RyRs in TC neurons in mice decreases their tonic firing rate while blocking them induces the opposite response. Furthermore, activation of RyRs in ventroposteriomedial/ ventroposteriolateral nuclei reduces the behavioral responses to inflammatory pain and blocking them increases the responses. This study highlights the importance of the intracellular Ca2+ release via RyRs in controlling the excitability of TC neurons and in inflammatory pain signal processing in the thalamus.",
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Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing. / Cheong, Eunji; Kim, Chanki; Choi, B. Jiwon; Sun, Minjeong; Shin, Hee Sup.

In: Journal of Neuroscience, Vol. 31, No. 4, 26.01.2011, p. 1213-1218.

Research output: Contribution to journalArticle

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AU - Cheong, Eunji

AU - Kim, Chanki

AU - Choi, B. Jiwon

AU - Sun, Minjeong

AU - Shin, Hee Sup

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