Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex

Jeongjin Kim, Jeonghoon Woo, Young Gyun Park, Sujin Chae, Seonmi Jo, Jeong Woo Choi, Hong Young Jun, Young Il Yeom, Seong Hoon Park, Kyunghwan Kim, Hee Sup Shin, Daesoo Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hypoxic damage to the prefrontal cortex (PFC) has been implicated in the frontal lobe dysfunction found in various neuropsychiatric disorders. The underlying subcortical mechanisms, however, have not been well explored. In this study, we induced a PFC-specific hypoxia-like damage by cobalt-wire implantation to demonstrate that the role of the mediodorsal thalamus (MD) is critical for the development of frontal lobe dysfunction, including frontal lobe-specific seizures and abnormal hyperactivity. Before the onset of these abnormalities, the cross talk between the MD and PFC nuclei at theta frequencies was enhanced. During the theta frequency interactions, burst spikes, known to depend on T-type Ca2+ channels, were increased in MD neurons. In vivo knockout or knockdown of the T-type Ca2+ channel gene (Ca V3.1) in the MD substantially reduced the theta frequency MD-PFC cross talk, frontal lobe-specific seizures, and locomotor hyperactivity in this model. These results suggest a two-step model of prefrontal dysfunction in which the response to a hypoxic lesion in the PFC results in abnormal thalamocortical feedback driven by thalamic T-type Ca2+ channels, which, in turn, leads to the onset of neurological and behavioral abnormalities. This study provides valuable insights into preventing the development of neuropsychiatric disorders arising from irreversible PFC damage.

Original languageEnglish
Pages (from-to)4063-4073
Number of pages11
JournalJournal of Neuroscience
Volume31
Issue number11
DOIs
Publication statusPublished - 2011 Mar 16

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Frontal Lobe
Prefrontal Cortex
Thalamus
Seizures
Cobalt
Hypoxia
Neurons
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kim, Jeongjin ; Woo, Jeonghoon ; Park, Young Gyun ; Chae, Sujin ; Jo, Seonmi ; Choi, Jeong Woo ; Jun, Hong Young ; Yeom, Young Il ; Park, Seong Hoon ; Kim, Kyunghwan ; Shin, Hee Sup ; Kim, Daesoo. / Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 11. pp. 4063-4073.
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Kim, J, Woo, J, Park, YG, Chae, S, Jo, S, Choi, JW, Jun, HY, Yeom, YI, Park, SH, Kim, K, Shin, HS & Kim, D 2011, 'Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex', Journal of Neuroscience, vol. 31, no. 11, pp. 4063-4073. https://doi.org/10.1523/JNEUROSCI.4493-10.2011

Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex. / Kim, Jeongjin; Woo, Jeonghoon; Park, Young Gyun; Chae, Sujin; Jo, Seonmi; Choi, Jeong Woo; Jun, Hong Young; Yeom, Young Il; Park, Seong Hoon; Kim, Kyunghwan; Shin, Hee Sup; Kim, Daesoo.

In: Journal of Neuroscience, Vol. 31, No. 11, 16.03.2011, p. 4063-4073.

Research output: Contribution to journalArticle

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