Thalamic volume and related visual recognition are associated with freezing of gait in non-demented patients with Parkinson's disease

Mun Kyung Sunwoo, Kyoo H. Cho, Jin Yong Hong, Ji E. Lee, Young H. Sohn, philhyu Lee

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17 Citations (Scopus)

Abstract

Background: The pathophysiology of freezing of gait (FOG) in non-demented Parkinson's disease (PD) patients remains poorly understood. Recent studies have suggested that neurochemical alterations in the cholinergic systems play a role in the development of FOG. Here, we evaluated the association between subcortical cholinergic structures and FOG in patients with non-demented PD. Methods: We recruited 46 non-demented patients with PD, categorized into PD with (n=16) and without FOG (n=30) groups. We performed neuropsychological test, region-of-interest-based volumetric analysis of the substantia innominata (SI) and automatic analysis of subcortical brain structures using a computerized segmentation procedure. Results: The comprehensive neuropsychological assessment showed that PD patients with FOG had lower cognitive performance in the frontal executive and visual-related functions compared with those without freezing of gait. The normalized SI volume did not differ significantly between the two groups (1.65±0.18 vs. 1.68±0.31). The automatic analysis of subcortical structures revealed that the thalamic volumes were significantly reduced in PD patients with FOG compared with those without FOG after adjusting for age, sex, disease duration, the Unified PD Rating Scale scores and total intracranial volume (left: 6.71 vs. 7.16cm3, p=0.029, right: 6.47 vs. 6.91cm3, p=0.026). Multiple linear regression analysis revealed that thalamic volume showed significant positive correlations with visual recognition memory (left: β=0.441, p=0.037, right: β=0.498, p=0.04). Conclusions: These data suggest that thalamic volume and related visual recognition, rather than the cortical cholinergic system arising from the SI, may be a major contributor to the development of freezing of gait in non-demented patients with PD.

Original languageEnglish
Pages (from-to)1106-1109
Number of pages4
JournalParkinsonism and Related Disorders
Volume19
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Gait
Freezing
Parkinson Disease
Substantia Innominata
Cholinergic Agents
Recognition (Psychology)
Neuropsychological Tests
Linear Models
Regression Analysis
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Sunwoo, Mun Kyung ; Cho, Kyoo H. ; Hong, Jin Yong ; Lee, Ji E. ; Sohn, Young H. ; Lee, philhyu. / Thalamic volume and related visual recognition are associated with freezing of gait in non-demented patients with Parkinson's disease. In: Parkinsonism and Related Disorders. 2013 ; Vol. 19, No. 12. pp. 1106-1109.
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Thalamic volume and related visual recognition are associated with freezing of gait in non-demented patients with Parkinson's disease. / Sunwoo, Mun Kyung; Cho, Kyoo H.; Hong, Jin Yong; Lee, Ji E.; Sohn, Young H.; Lee, philhyu.

In: Parkinsonism and Related Disorders, Vol. 19, No. 12, 01.12.2013, p. 1106-1109.

Research output: Contribution to journalArticle

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T1 - Thalamic volume and related visual recognition are associated with freezing of gait in non-demented patients with Parkinson's disease

AU - Sunwoo, Mun Kyung

AU - Cho, Kyoo H.

AU - Hong, Jin Yong

AU - Lee, Ji E.

AU - Sohn, Young H.

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AB - Background: The pathophysiology of freezing of gait (FOG) in non-demented Parkinson's disease (PD) patients remains poorly understood. Recent studies have suggested that neurochemical alterations in the cholinergic systems play a role in the development of FOG. Here, we evaluated the association between subcortical cholinergic structures and FOG in patients with non-demented PD. Methods: We recruited 46 non-demented patients with PD, categorized into PD with (n=16) and without FOG (n=30) groups. We performed neuropsychological test, region-of-interest-based volumetric analysis of the substantia innominata (SI) and automatic analysis of subcortical brain structures using a computerized segmentation procedure. Results: The comprehensive neuropsychological assessment showed that PD patients with FOG had lower cognitive performance in the frontal executive and visual-related functions compared with those without freezing of gait. The normalized SI volume did not differ significantly between the two groups (1.65±0.18 vs. 1.68±0.31). The automatic analysis of subcortical structures revealed that the thalamic volumes were significantly reduced in PD patients with FOG compared with those without FOG after adjusting for age, sex, disease duration, the Unified PD Rating Scale scores and total intracranial volume (left: 6.71 vs. 7.16cm3, p=0.029, right: 6.47 vs. 6.91cm3, p=0.026). Multiple linear regression analysis revealed that thalamic volume showed significant positive correlations with visual recognition memory (left: β=0.441, p=0.037, right: β=0.498, p=0.04). Conclusions: These data suggest that thalamic volume and related visual recognition, rather than the cortical cholinergic system arising from the SI, may be a major contributor to the development of freezing of gait in non-demented patients with PD.

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