The -1131T→C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men

Yangsoo Jang, Young Kim Ji, Yoen Kim Oh, Eun Lee Jong, Hongkeun Cho, Jose M. Ordovas, Jong Ho Lee

Research output: Contribution to journalArticle

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Abstract

Background: Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models. Objective: The objective was to determine associations of the common apolipoprotein A5 gene (APOA 5) -1131T→C polymorphism with postprandial lipemic response and other cardiovascular disease risk factors in humans. Design: Healthy, nonobese subjects [n = 158; mean (±SEM) age: 33.8 ± 1.2 y; body mass index (in kg/m 2): 23.3 ± 0.3] were subdivided into 3 genotype groups: TT (n = 85), TC (n = 56), and CC (n = 17). We measured fasting and postprandial lipid concentrations, lipid peroxidation, C-reactive protein concentrations, and DNA damage. Results: Fasting triacylglycerol concentrations in carriers of the C allele were higher (P < 0.05) than in carriers of the TT genotype. No other significant genotype-related differences were observed for any of the other baseline measures. After consumption of a mixed meal, carriers of the C allele had significantly greater increases in total chylomicron and VLDL triacylglycerol than did subjects with the TT genotype. Moreover, carriers of the C allele had higher dense LDL, serum C-reactive protein, and urinary 8-epi-prostaglandin F concentrations and more lymphocyte DNA damage. Conversely, we did not find significant genotype-related differences in postprandial glucose, insulin, or free fatty acid measures. Conclusions: Our data confirm the genetic modulation of serum fasting triacylglycerol concentrations by the APOA5 gene polymorphism and extend this observation to postprandial triacylglycerol concentrations and to markers of oxidation and inflammation. The presence of the C allele in the APOA5 promoter region at position 1131 could be a significant factor contributing to higher cardiovascular disease risk in Koreans independently of common environmental factors.

Original languageEnglish
Pages (from-to)832-840
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume80
Issue number4
Publication statusPublished - 2004 Oct 1

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Oxidative Stress
Genotype
Triglycerides
Alleles
Fasting
Genes
C-Reactive Protein
DNA Damage
Cardiovascular Diseases
Chylomicrons
Prostaglandins F
Nonesterified Fatty Acids
Genetic Promoter Regions
Lipid Peroxidation
Meals
Blood Proteins
Healthy Volunteers
Body Mass Index
Animal Models
oxidized low density lipoprotein

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{4cefda17c6f04c9dbccf5dcc32bea88a,
title = "The -1131T→C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men",
abstract = "Background: Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models. Objective: The objective was to determine associations of the common apolipoprotein A5 gene (APOA 5) -1131T→C polymorphism with postprandial lipemic response and other cardiovascular disease risk factors in humans. Design: Healthy, nonobese subjects [n = 158; mean (±SEM) age: 33.8 ± 1.2 y; body mass index (in kg/m 2): 23.3 ± 0.3] were subdivided into 3 genotype groups: TT (n = 85), TC (n = 56), and CC (n = 17). We measured fasting and postprandial lipid concentrations, lipid peroxidation, C-reactive protein concentrations, and DNA damage. Results: Fasting triacylglycerol concentrations in carriers of the C allele were higher (P < 0.05) than in carriers of the TT genotype. No other significant genotype-related differences were observed for any of the other baseline measures. After consumption of a mixed meal, carriers of the C allele had significantly greater increases in total chylomicron and VLDL triacylglycerol than did subjects with the TT genotype. Moreover, carriers of the C allele had higher dense LDL, serum C-reactive protein, and urinary 8-epi-prostaglandin F 2α concentrations and more lymphocyte DNA damage. Conversely, we did not find significant genotype-related differences in postprandial glucose, insulin, or free fatty acid measures. Conclusions: Our data confirm the genetic modulation of serum fasting triacylglycerol concentrations by the APOA5 gene polymorphism and extend this observation to postprandial triacylglycerol concentrations and to markers of oxidation and inflammation. The presence of the C allele in the APOA5 promoter region at position 1131 could be a significant factor contributing to higher cardiovascular disease risk in Koreans independently of common environmental factors.",
author = "Yangsoo Jang and Ji, {Young Kim} and Oh, {Yoen Kim} and Jong, {Eun Lee} and Hongkeun Cho and Ordovas, {Jose M.} and Lee, {Jong Ho}",
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pages = "832--840",
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The -1131T→C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men. / Jang, Yangsoo; Ji, Young Kim; Oh, Yoen Kim; Jong, Eun Lee; Cho, Hongkeun; Ordovas, Jose M.; Lee, Jong Ho.

In: American Journal of Clinical Nutrition, Vol. 80, No. 4, 01.10.2004, p. 832-840.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The -1131T→C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men

AU - Jang, Yangsoo

AU - Ji, Young Kim

AU - Oh, Yoen Kim

AU - Jong, Eun Lee

AU - Cho, Hongkeun

AU - Ordovas, Jose M.

AU - Lee, Jong Ho

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Background: Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models. Objective: The objective was to determine associations of the common apolipoprotein A5 gene (APOA 5) -1131T→C polymorphism with postprandial lipemic response and other cardiovascular disease risk factors in humans. Design: Healthy, nonobese subjects [n = 158; mean (±SEM) age: 33.8 ± 1.2 y; body mass index (in kg/m 2): 23.3 ± 0.3] were subdivided into 3 genotype groups: TT (n = 85), TC (n = 56), and CC (n = 17). We measured fasting and postprandial lipid concentrations, lipid peroxidation, C-reactive protein concentrations, and DNA damage. Results: Fasting triacylglycerol concentrations in carriers of the C allele were higher (P < 0.05) than in carriers of the TT genotype. No other significant genotype-related differences were observed for any of the other baseline measures. After consumption of a mixed meal, carriers of the C allele had significantly greater increases in total chylomicron and VLDL triacylglycerol than did subjects with the TT genotype. Moreover, carriers of the C allele had higher dense LDL, serum C-reactive protein, and urinary 8-epi-prostaglandin F 2α concentrations and more lymphocyte DNA damage. Conversely, we did not find significant genotype-related differences in postprandial glucose, insulin, or free fatty acid measures. Conclusions: Our data confirm the genetic modulation of serum fasting triacylglycerol concentrations by the APOA5 gene polymorphism and extend this observation to postprandial triacylglycerol concentrations and to markers of oxidation and inflammation. The presence of the C allele in the APOA5 promoter region at position 1131 could be a significant factor contributing to higher cardiovascular disease risk in Koreans independently of common environmental factors.

AB - Background: Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models. Objective: The objective was to determine associations of the common apolipoprotein A5 gene (APOA 5) -1131T→C polymorphism with postprandial lipemic response and other cardiovascular disease risk factors in humans. Design: Healthy, nonobese subjects [n = 158; mean (±SEM) age: 33.8 ± 1.2 y; body mass index (in kg/m 2): 23.3 ± 0.3] were subdivided into 3 genotype groups: TT (n = 85), TC (n = 56), and CC (n = 17). We measured fasting and postprandial lipid concentrations, lipid peroxidation, C-reactive protein concentrations, and DNA damage. Results: Fasting triacylglycerol concentrations in carriers of the C allele were higher (P < 0.05) than in carriers of the TT genotype. No other significant genotype-related differences were observed for any of the other baseline measures. After consumption of a mixed meal, carriers of the C allele had significantly greater increases in total chylomicron and VLDL triacylglycerol than did subjects with the TT genotype. Moreover, carriers of the C allele had higher dense LDL, serum C-reactive protein, and urinary 8-epi-prostaglandin F 2α concentrations and more lymphocyte DNA damage. Conversely, we did not find significant genotype-related differences in postprandial glucose, insulin, or free fatty acid measures. Conclusions: Our data confirm the genetic modulation of serum fasting triacylglycerol concentrations by the APOA5 gene polymorphism and extend this observation to postprandial triacylglycerol concentrations and to markers of oxidation and inflammation. The presence of the C allele in the APOA5 promoter region at position 1131 could be a significant factor contributing to higher cardiovascular disease risk in Koreans independently of common environmental factors.

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