The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke

Jong Youl Kim, Yeonseung Han, Jong Eun Lee, Midori A. Yenari

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Introduction: The 70-kDa heat shock protein (Hsp70) is a cytosolic chaperone which facilitates protein folding, degradation, complex assembly, and translocation. Following stroke, these functions have the potential to lead to cytoprotection, and this has been demonstrated using genetic mutant models, direct gene transfer or the induction of Hsp70 via heat stress, approaches which limit its translational utility. Recently, the investigation of Hsp70-inducing pharmacological compounds, which, through their ability to inhibit Hsp90, has obvious clinical implications in terms of potential therapies to mitigate cell death and inflammation, and lead to neuroprotection from brain injury. Areas covered: In this review, we will focus on the role of Hsp70 in cell death and inflammation, and the current literature surrounding the pharmacological induction in acute ischemic stroke models with comments on potential applications at the clinical level. Expert opinion: Such neuroprotectants could be used to synergistically improve neurological outcome or to extend the time window of existing interventions, thus increasing the numbers of stroke victims eligible for treatment.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Volume22
Issue number3
DOIs
Publication statusPublished - 2018 Mar 4

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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