The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study

Hyun Ha Chang, Won Kee Lee, Chisook Moon, Won Suk Choi, Hee Jung Yoon, Jieun Kim, Seong Yeol Ryu, Hyun Ah Kim, Yu Mi Jo, Ki Tae Kwon, Hye In Kim, Jang Wook Sohn, Young Kyung Yoon, Sook In Jung, Kyung Hwa Park, Hyun Hee Kwon, Mi Suk Lee, Young Keun Kim, Yeon Sook Kim, Jian HurShin Woo Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalAmerican Journal of Infection Control
Volume44
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Occupational Exposure
Hepatitis B
Hepatitis B virus
Multicenter Studies
Immunoglobulins
Injections
Delivery of Health Care
Virus Diseases
Hepatitis Antibodies
Hepatitis B Antibodies
Hospital Records
Infection Control
Tertiary Care Centers
Teaching Hospitals
Vaccination

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Chang, Hyun Ha ; Lee, Won Kee ; Moon, Chisook ; Choi, Won Suk ; Yoon, Hee Jung ; Kim, Jieun ; Ryu, Seong Yeol ; Kim, Hyun Ah ; Jo, Yu Mi ; Kwon, Ki Tae ; Kim, Hye In ; Sohn, Jang Wook ; Yoon, Young Kyung ; Jung, Sook In ; Park, Kyung Hwa ; Kwon, Hyun Hee ; Lee, Mi Suk ; Kim, Young Keun ; Kim, Yeon Sook ; Hur, Jian ; Kim, Shin Woo. / The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection : Results from a Korean nationwide, multicenter study. In: American Journal of Infection Control. 2016 ; Vol. 44, No. 2. pp. 189-193.
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title = "The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study",
abstract = "Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2{\%}) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93{\%} of cases. In 98 cases (68.5{\%}), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5{\%}) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5{\%} received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.",
author = "Chang, {Hyun Ha} and Lee, {Won Kee} and Chisook Moon and Choi, {Won Suk} and Yoon, {Hee Jung} and Jieun Kim and Ryu, {Seong Yeol} and Kim, {Hyun Ah} and Jo, {Yu Mi} and Kwon, {Ki Tae} and Kim, {Hye In} and Sohn, {Jang Wook} and Yoon, {Young Kyung} and Jung, {Sook In} and Park, {Kyung Hwa} and Kwon, {Hyun Hee} and Lee, {Mi Suk} and Kim, {Young Keun} and Kim, {Yeon Sook} and Jian Hur and Kim, {Shin Woo}",
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Chang, HH, Lee, WK, Moon, C, Choi, WS, Yoon, HJ, Kim, J, Ryu, SY, Kim, HA, Jo, YM, Kwon, KT, Kim, HI, Sohn, JW, Yoon, YK, Jung, SI, Park, KH, Kwon, HH, Lee, MS, Kim, YK, Kim, YS, Hur, J & Kim, SW 2016, 'The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study', American Journal of Infection Control, vol. 44, no. 2, pp. 189-193. https://doi.org/10.1016/j.ajic.2015.08.024

The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection : Results from a Korean nationwide, multicenter study. / Chang, Hyun Ha; Lee, Won Kee; Moon, Chisook; Choi, Won Suk; Yoon, Hee Jung; Kim, Jieun; Ryu, Seong Yeol; Kim, Hyun Ah; Jo, Yu Mi; Kwon, Ki Tae; Kim, Hye In; Sohn, Jang Wook; Yoon, Young Kyung; Jung, Sook In; Park, Kyung Hwa; Kwon, Hyun Hee; Lee, Mi Suk; Kim, Young Keun; Kim, Yeon Sook; Hur, Jian; Kim, Shin Woo.

In: American Journal of Infection Control, Vol. 44, No. 2, 01.02.2016, p. 189-193.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection

T2 - Results from a Korean nationwide, multicenter study

AU - Chang, Hyun Ha

AU - Lee, Won Kee

AU - Moon, Chisook

AU - Choi, Won Suk

AU - Yoon, Hee Jung

AU - Kim, Jieun

AU - Ryu, Seong Yeol

AU - Kim, Hyun Ah

AU - Jo, Yu Mi

AU - Kwon, Ki Tae

AU - Kim, Hye In

AU - Sohn, Jang Wook

AU - Yoon, Young Kyung

AU - Jung, Sook In

AU - Park, Kyung Hwa

AU - Kwon, Hyun Hee

AU - Lee, Mi Suk

AU - Kim, Young Keun

AU - Kim, Yeon Sook

AU - Hur, Jian

AU - Kim, Shin Woo

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.

AB - Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.

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