The accuracy of ultrasonography for the evaluation of portal hypertension in patients with cirrhosis: A systematic review

Gaeun Kim, Youn Zoo Cho, Soon Koo Baik, Moon Young Kim, Won Ki Hong, Sang Ok Kwon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Studies have presented conflicting results regarding the accuracy of ultrasonography (US) for diagnosing portal hypertension (PH). We sought to identify evidence in the literature regarding the accuracy of US for assessing PH in patients with liver cirrhosis. Materials and Methods: We conducted a systematic review by searching databases, including MEDLINE, EMBASE, and the Cochrane Library, for relevant studies. Results: A total of 14 studies met our inclusion criteria. The US indices were obtained in the portal vein (n = 9), hepatic artery (n = 6), hepatic vein (HV) (n = 4) and other vessels. Using hepatic venous pressure gradient (HVPG) as the reference, the sensitivity (Se) and specificity (Sp) of the portal venous indices were 69–88% and 67–75%, respectively. The correlation coefficients between HVPG and the portal venous indices were approximately 0.296–0.8. No studies assess the Se and Sp of the hepatic arterial indices. The correlation between HVPG and the hepatic arterial indices ranged from 0.01 to 0.83. The Se and Sp of the hepatic venous indices were 75.9–77.8% and 81.8–100%, respectively. In particular, the Se and Sp of HV arrival time for clinically significant PH were 92.7% and 86.7%, respectively. A statistically significant correlation between HVPG and the hepatic venous indices was observed (0.545–0.649). Conclusion: Some US indices, such as HV, exhibited an increased accuracy for diagnosing PH. These indices may be useful in clinical practice for the detection of significant PH.

Original languageEnglish
Pages (from-to)314-324
Number of pages11
JournalKorean journal of radiology
Volume16
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

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Portal Hypertension
Ultrasonography
Fibrosis
Venous Pressure
Liver
Hepatic Veins
Sensitivity and Specificity
Hepatic Artery
Portal Vein
MEDLINE
Liver Cirrhosis
Libraries
Databases

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "The accuracy of ultrasonography for the evaluation of portal hypertension in patients with cirrhosis: A systematic review",
abstract = "Objective: Studies have presented conflicting results regarding the accuracy of ultrasonography (US) for diagnosing portal hypertension (PH). We sought to identify evidence in the literature regarding the accuracy of US for assessing PH in patients with liver cirrhosis. Materials and Methods: We conducted a systematic review by searching databases, including MEDLINE, EMBASE, and the Cochrane Library, for relevant studies. Results: A total of 14 studies met our inclusion criteria. The US indices were obtained in the portal vein (n = 9), hepatic artery (n = 6), hepatic vein (HV) (n = 4) and other vessels. Using hepatic venous pressure gradient (HVPG) as the reference, the sensitivity (Se) and specificity (Sp) of the portal venous indices were 69–88{\%} and 67–75{\%}, respectively. The correlation coefficients between HVPG and the portal venous indices were approximately 0.296–0.8. No studies assess the Se and Sp of the hepatic arterial indices. The correlation between HVPG and the hepatic arterial indices ranged from 0.01 to 0.83. The Se and Sp of the hepatic venous indices were 75.9–77.8{\%} and 81.8–100{\%}, respectively. In particular, the Se and Sp of HV arrival time for clinically significant PH were 92.7{\%} and 86.7{\%}, respectively. A statistically significant correlation between HVPG and the hepatic venous indices was observed (0.545–0.649). Conclusion: Some US indices, such as HV, exhibited an increased accuracy for diagnosing PH. These indices may be useful in clinical practice for the detection of significant PH.",
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The accuracy of ultrasonography for the evaluation of portal hypertension in patients with cirrhosis : A systematic review. / Kim, Gaeun; Cho, Youn Zoo; Baik, Soon Koo; Kim, Moon Young; Hong, Won Ki; Kwon, Sang Ok.

In: Korean journal of radiology, Vol. 16, No. 2, 01.01.2015, p. 314-324.

Research output: Contribution to journalArticle

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T1 - The accuracy of ultrasonography for the evaluation of portal hypertension in patients with cirrhosis

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AU - Cho, Youn Zoo

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AU - Hong, Won Ki

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N2 - Objective: Studies have presented conflicting results regarding the accuracy of ultrasonography (US) for diagnosing portal hypertension (PH). We sought to identify evidence in the literature regarding the accuracy of US for assessing PH in patients with liver cirrhosis. Materials and Methods: We conducted a systematic review by searching databases, including MEDLINE, EMBASE, and the Cochrane Library, for relevant studies. Results: A total of 14 studies met our inclusion criteria. The US indices were obtained in the portal vein (n = 9), hepatic artery (n = 6), hepatic vein (HV) (n = 4) and other vessels. Using hepatic venous pressure gradient (HVPG) as the reference, the sensitivity (Se) and specificity (Sp) of the portal venous indices were 69–88% and 67–75%, respectively. The correlation coefficients between HVPG and the portal venous indices were approximately 0.296–0.8. No studies assess the Se and Sp of the hepatic arterial indices. The correlation between HVPG and the hepatic arterial indices ranged from 0.01 to 0.83. The Se and Sp of the hepatic venous indices were 75.9–77.8% and 81.8–100%, respectively. In particular, the Se and Sp of HV arrival time for clinically significant PH were 92.7% and 86.7%, respectively. A statistically significant correlation between HVPG and the hepatic venous indices was observed (0.545–0.649). Conclusion: Some US indices, such as HV, exhibited an increased accuracy for diagnosing PH. These indices may be useful in clinical practice for the detection of significant PH.

AB - Objective: Studies have presented conflicting results regarding the accuracy of ultrasonography (US) for diagnosing portal hypertension (PH). We sought to identify evidence in the literature regarding the accuracy of US for assessing PH in patients with liver cirrhosis. Materials and Methods: We conducted a systematic review by searching databases, including MEDLINE, EMBASE, and the Cochrane Library, for relevant studies. Results: A total of 14 studies met our inclusion criteria. The US indices were obtained in the portal vein (n = 9), hepatic artery (n = 6), hepatic vein (HV) (n = 4) and other vessels. Using hepatic venous pressure gradient (HVPG) as the reference, the sensitivity (Se) and specificity (Sp) of the portal venous indices were 69–88% and 67–75%, respectively. The correlation coefficients between HVPG and the portal venous indices were approximately 0.296–0.8. No studies assess the Se and Sp of the hepatic arterial indices. The correlation between HVPG and the hepatic arterial indices ranged from 0.01 to 0.83. The Se and Sp of the hepatic venous indices were 75.9–77.8% and 81.8–100%, respectively. In particular, the Se and Sp of HV arrival time for clinically significant PH were 92.7% and 86.7%, respectively. A statistically significant correlation between HVPG and the hepatic venous indices was observed (0.545–0.649). Conclusion: Some US indices, such as HV, exhibited an increased accuracy for diagnosing PH. These indices may be useful in clinical practice for the detection of significant PH.

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