Gymnema sylvestre is known for its potent antidiabetic activity. Phytochemical investigations of this plant led to the isolation of three new pregnane glycosides, gymnepregosides R-T (1-3) and four known analogues, 12β-acetyloxy-3β,8β,14β,17β-tetrahydroxypregn-5-en-20-one 3-O-β-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (4), 12-O-(E)-cinnamoylgymnepregoside F (5), gymnepregoside F (6), and stephanoside I (7). Their structures were identified based on spectroscopic evidence and compared with those reported in the literature. All compounds were evaluated for antiglycative inhibitory activity. Compounds 1, 3, 5, and 6 showed the inhibitory effect on BSA-MGO formation ranging from 6.0 to 8.8 % at the concentrations of 400 μM. Compounds 1 and 2 showed significant breaking properties on MGO-AGE-protein crosslink with percent modification ranging from 54.6 to 58.4 %. Notably, a novel AGEs inhibitor (1) may inhibit the formation and accumulation of MGO-AGEs and protect cells from MGO-AGEs cross-linking damage.
|Number of pages||6|
|Publication status||Published - 2020 Aug|
Bibliographical noteFunding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.25 and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea .
© 2020 Phytochemical Society of Europe
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- Plant Science