The anti-glycative potentials of pregnane glycosides from Gymnema sylvestre

Phan Van Kiem, Duong Thi Hai Yen, Nguyen Van Hung, Nguyen Xuan Nhiem, Bui Huu Tai, Do Thi Trang, Pham Hai Yen, Hoang Duc Manh, Chau Van Minh, Seon Ju Park, Jae Hyuk Lee, Sun Yeou Kim, Seung Hyun Kim

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3 Citations (Scopus)


Gymnema sylvestre is known for its potent antidiabetic activity. Phytochemical investigations of this plant led to the isolation of three new pregnane glycosides, gymnepregosides R-T (1-3) and four known analogues, 12β-acetyloxy-3β,8β,14β,17β-tetrahydroxypregn-5-en-20-one 3-O-β-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (4), 12-O-(E)-cinnamoylgymnepregoside F (5), gymnepregoside F (6), and stephanoside I (7). Their structures were identified based on spectroscopic evidence and compared with those reported in the literature. All compounds were evaluated for antiglycative inhibitory activity. Compounds 1, 3, 5, and 6 showed the inhibitory effect on BSA-MGO formation ranging from 6.0 to 8.8 % at the concentrations of 400 μM. Compounds 1 and 2 showed significant breaking properties on MGO-AGE-protein crosslink with percent modification ranging from 54.6 to 58.4 %. Notably, a novel AGEs inhibitor (1) may inhibit the formation and accumulation of MGO-AGEs and protect cells from MGO-AGEs cross-linking damage.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalPhytochemistry Letters
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.25 and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea .

Publisher Copyright:
© 2020 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science


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