The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population

Jae Youn Moon, Sungha Park, Ji Hyuk Rhee, Sun Ha Jee, Chan Mi Park, Dae Sik Choi, Hyun Young Park, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

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Abstract

Background: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome (MetS). [We applied four criteria of MetS: the NCEP criteria, the Asian modified NCEP (a-NCEP) criteria, the WHO criteria and the Asian modified WHO (a-WHO).]. Methods: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criteria of the MetS were applied for the study population. Results: Among the 2724 participants, 522 (19.2%) met the NCEP criteria, 796 (29.2%) met the a-NCEP criteria, 361 (13.3%) met the WHO criteria and 576 (21.1%) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using the different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria (odd ratio: 1.755 [95% CI: 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. Conclusions: All the MetS criteria showed similar metabolic profiles and all four criteria had similar predictive value for CAD. Conventional MetS criteria, applied to the non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criteria.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalInternational Journal of Cardiology
Volume114
Issue number1
DOIs
Publication statusPublished - 2007 Jan 2

Fingerprint

Coronary Artery Disease
Population
Metabolome
Apolipoproteins B
Odds Ratio
Genome
Insulin
Lipids
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Moon, Jae Youn ; Park, Sungha ; Rhee, Ji Hyuk ; Jee, Sun Ha ; Park, Chan Mi ; Choi, Dae Sik ; Park, Hyun Young ; Ko, Young Guk ; Choi, Donghoon ; Jang, Yangsoo ; Chung, Namsik. / The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population. In: International Journal of Cardiology. 2007 ; Vol. 114, No. 1. pp. 83-89.
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title = "The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population",
abstract = "Background: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome (MetS). [We applied four criteria of MetS: the NCEP criteria, the Asian modified NCEP (a-NCEP) criteria, the WHO criteria and the Asian modified WHO (a-WHO).]. Methods: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criteria of the MetS were applied for the study population. Results: Among the 2724 participants, 522 (19.2{\%}) met the NCEP criteria, 796 (29.2{\%}) met the a-NCEP criteria, 361 (13.3{\%}) met the WHO criteria and 576 (21.1{\%}) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using the different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria (odd ratio: 1.755 [95{\%} CI: 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. Conclusions: All the MetS criteria showed similar metabolic profiles and all four criteria had similar predictive value for CAD. Conventional MetS criteria, applied to the non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criteria.",
author = "Moon, {Jae Youn} and Sungha Park and Rhee, {Ji Hyuk} and Jee, {Sun Ha} and Park, {Chan Mi} and Choi, {Dae Sik} and Park, {Hyun Young} and Ko, {Young Guk} and Donghoon Choi and Yangsoo Jang and Namsik Chung",
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The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population. / Moon, Jae Youn; Park, Sungha; Rhee, Ji Hyuk; Jee, Sun Ha; Park, Chan Mi; Choi, Dae Sik; Park, Hyun Young; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik.

In: International Journal of Cardiology, Vol. 114, No. 1, 02.01.2007, p. 83-89.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population

AU - Moon, Jae Youn

AU - Park, Sungha

AU - Rhee, Ji Hyuk

AU - Jee, Sun Ha

AU - Park, Chan Mi

AU - Choi, Dae Sik

AU - Park, Hyun Young

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2007/1/2

Y1 - 2007/1/2

N2 - Background: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome (MetS). [We applied four criteria of MetS: the NCEP criteria, the Asian modified NCEP (a-NCEP) criteria, the WHO criteria and the Asian modified WHO (a-WHO).]. Methods: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criteria of the MetS were applied for the study population. Results: Among the 2724 participants, 522 (19.2%) met the NCEP criteria, 796 (29.2%) met the a-NCEP criteria, 361 (13.3%) met the WHO criteria and 576 (21.1%) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using the different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria (odd ratio: 1.755 [95% CI: 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. Conclusions: All the MetS criteria showed similar metabolic profiles and all four criteria had similar predictive value for CAD. Conventional MetS criteria, applied to the non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criteria.

AB - Background: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome (MetS). [We applied four criteria of MetS: the NCEP criteria, the Asian modified NCEP (a-NCEP) criteria, the WHO criteria and the Asian modified WHO (a-WHO).]. Methods: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criteria of the MetS were applied for the study population. Results: Among the 2724 participants, 522 (19.2%) met the NCEP criteria, 796 (29.2%) met the a-NCEP criteria, 361 (13.3%) met the WHO criteria and 576 (21.1%) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using the different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria (odd ratio: 1.755 [95% CI: 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. Conclusions: All the MetS criteria showed similar metabolic profiles and all four criteria had similar predictive value for CAD. Conventional MetS criteria, applied to the non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criteria.

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