The association between adiponectin and diabetes in the Korean population

Soo Jin Yoon, Hong Soo Lee, Sang Wha Lee, Ji Eun Yun, Sang Yon Kim, Eo Rin Cho, Sun Ju Lee, Eun Jung Jee, Hee Yeon Lee, Jungyong Park, Hyon Suk Kim, Sun Ha Jee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume57
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

Fingerprint

Adiponectin
Waist Circumference
Body Mass Index
Population
Obesity
HDL Cholesterol
HDL Lipoproteins
Serum
Life Style
Fasting
Diabetes Mellitus
Logistic Models
Regression Analysis
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Yoon, S. J., Lee, H. S., Lee, S. W., Yun, J. E., Kim, S. Y., Cho, E. R., ... Jee, S. H. (2008). The association between adiponectin and diabetes in the Korean population. Metabolism: Clinical and Experimental, 57(6), 853-857. https://doi.org/10.1016/j.metabol.2008.01.031
Yoon, Soo Jin ; Lee, Hong Soo ; Lee, Sang Wha ; Yun, Ji Eun ; Kim, Sang Yon ; Cho, Eo Rin ; Lee, Sun Ju ; Jee, Eun Jung ; Lee, Hee Yeon ; Park, Jungyong ; Kim, Hyon Suk ; Jee, Sun Ha. / The association between adiponectin and diabetes in the Korean population. In: Metabolism: Clinical and Experimental. 2008 ; Vol. 57, No. 6. pp. 853-857.
@article{476752c8b6164f04a777d3e57c465a4c,
title = "The association between adiponectin and diabetes in the Korean population",
abstract = "As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes.",
author = "Yoon, {Soo Jin} and Lee, {Hong Soo} and Lee, {Sang Wha} and Yun, {Ji Eun} and Kim, {Sang Yon} and Cho, {Eo Rin} and Lee, {Sun Ju} and Jee, {Eun Jung} and Lee, {Hee Yeon} and Jungyong Park and Kim, {Hyon Suk} and Jee, {Sun Ha}",
year = "2008",
month = "6",
day = "1",
doi = "10.1016/j.metabol.2008.01.031",
language = "English",
volume = "57",
pages = "853--857",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "6",

}

Yoon, SJ, Lee, HS, Lee, SW, Yun, JE, Kim, SY, Cho, ER, Lee, SJ, Jee, EJ, Lee, HY, Park, J, Kim, HS & Jee, SH 2008, 'The association between adiponectin and diabetes in the Korean population', Metabolism: Clinical and Experimental, vol. 57, no. 6, pp. 853-857. https://doi.org/10.1016/j.metabol.2008.01.031

The association between adiponectin and diabetes in the Korean population. / Yoon, Soo Jin; Lee, Hong Soo; Lee, Sang Wha; Yun, Ji Eun; Kim, Sang Yon; Cho, Eo Rin; Lee, Sun Ju; Jee, Eun Jung; Lee, Hee Yeon; Park, Jungyong; Kim, Hyon Suk; Jee, Sun Ha.

In: Metabolism: Clinical and Experimental, Vol. 57, No. 6, 01.06.2008, p. 853-857.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between adiponectin and diabetes in the Korean population

AU - Yoon, Soo Jin

AU - Lee, Hong Soo

AU - Lee, Sang Wha

AU - Yun, Ji Eun

AU - Kim, Sang Yon

AU - Cho, Eo Rin

AU - Lee, Sun Ju

AU - Jee, Eun Jung

AU - Lee, Hee Yeon

AU - Park, Jungyong

AU - Kim, Hyon Suk

AU - Jee, Sun Ha

PY - 2008/6/1

Y1 - 2008/6/1

N2 - As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes.

AB - As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well-known risk factors for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. The WC, BMI, and serum adiponectin were measured in 4459 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high-density lipoprotein (HDL) cholesterol (P < .001). After adjusting for age, BMI, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in women but not men. The combined effects of WC and adiponectin on diabetes progressively increased; however, the interaction of these 2 variables was not statistically significant. The combined effect of BMI and adiponectin on diabetes showed similar results. These results suggest that adiponectin was associated with diabetes. The association was independent of BMI and WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC and BMI on diabetes.

UR - http://www.scopus.com/inward/record.url?scp=43849092085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43849092085&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2008.01.031

DO - 10.1016/j.metabol.2008.01.031

M3 - Article

C2 - 18502270

AN - SCOPUS:43849092085

VL - 57

SP - 853

EP - 857

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 6

ER -