The association between blood cadmium level and airflow obstruction in Korean men

JinHa Yoon, Inah Kim, Hyoung Ryoul Kim, Jong Uk Won, Kyu Jung Bae, Pil Kyun Jung, Jaehoon Roh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Most humans are exposed to environmental contaminants via inhalation. Various toxic inhalants cause lung damage with pathologic changes to the airway system. Lung function decline is an important cause of morbidity and mortality worldwide.Aim: To consider the potential burden of cadmium on pulmonary disease, this study examined the relationship between blood cadmium levels and airflow obstruction in a Korean general population.Subjects and methods: Data from the Korean National Health and Nutrition Examination Surveys from 2008-2011 were used. Male participants were selected who were older than 40 years, who had completed a reliable pulmonary function test and for who measurements of blood cadmium levels were available (n = 1974). The pulmonary function tests were undertaken and airflow obstruction was defined when forced vital capacity/forced expiratory volume in 1 second ratio < 0.7.Results: In an age-adjusted logistic regression model, blood cadmium levels correlated with the risk of obstructive airflow pattern in total participants as well as in smokers or never smokers. Further adjustment for BMI, current occupation and educational level did not attenuate these associations among total participants, smokers and never smokers (OR = 2.53, 95% CI = 1.83-3.50 in total; OR = 2.17, 95% CI = 1.55-3.02 in smokers; OR = 3.71, 95% CI = 1.48-9.33 in never smokers).Conclusions: In conclusion, blood cadmium level was associated with airflow obstruction independently of smoking history and that association was still significant in never smokers. Careful attention is needed for the general population who are potentially exposed to cadmium.

Original languageEnglish
Pages (from-to)569-575
Number of pages7
JournalAnnals of human biology
Volume42
Issue number6
DOIs
Publication statusPublished - 2015 Nov 2

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Cadmium
Respiratory Function Tests
Logistic Models
Lung
Nutrition Surveys
Poisons
Vital Capacity
Forced Expiratory Volume
Occupations
Inhalation
Population
Lung Diseases
Smoking
History
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Physiology
  • Ageing
  • Genetics
  • Public Health, Environmental and Occupational Health

Cite this

Yoon, JinHa ; Kim, Inah ; Kim, Hyoung Ryoul ; Won, Jong Uk ; Bae, Kyu Jung ; Jung, Pil Kyun ; Roh, Jaehoon. / The association between blood cadmium level and airflow obstruction in Korean men. In: Annals of human biology. 2015 ; Vol. 42, No. 6. pp. 569-575.
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The association between blood cadmium level and airflow obstruction in Korean men. / Yoon, JinHa; Kim, Inah; Kim, Hyoung Ryoul; Won, Jong Uk; Bae, Kyu Jung; Jung, Pil Kyun; Roh, Jaehoon.

In: Annals of human biology, Vol. 42, No. 6, 02.11.2015, p. 569-575.

Research output: Contribution to journalArticle

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T1 - The association between blood cadmium level and airflow obstruction in Korean men

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AU - Kim, Hyoung Ryoul

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N2 - Background: Most humans are exposed to environmental contaminants via inhalation. Various toxic inhalants cause lung damage with pathologic changes to the airway system. Lung function decline is an important cause of morbidity and mortality worldwide.Aim: To consider the potential burden of cadmium on pulmonary disease, this study examined the relationship between blood cadmium levels and airflow obstruction in a Korean general population.Subjects and methods: Data from the Korean National Health and Nutrition Examination Surveys from 2008-2011 were used. Male participants were selected who were older than 40 years, who had completed a reliable pulmonary function test and for who measurements of blood cadmium levels were available (n = 1974). The pulmonary function tests were undertaken and airflow obstruction was defined when forced vital capacity/forced expiratory volume in 1 second ratio < 0.7.Results: In an age-adjusted logistic regression model, blood cadmium levels correlated with the risk of obstructive airflow pattern in total participants as well as in smokers or never smokers. Further adjustment for BMI, current occupation and educational level did not attenuate these associations among total participants, smokers and never smokers (OR = 2.53, 95% CI = 1.83-3.50 in total; OR = 2.17, 95% CI = 1.55-3.02 in smokers; OR = 3.71, 95% CI = 1.48-9.33 in never smokers).Conclusions: In conclusion, blood cadmium level was associated with airflow obstruction independently of smoking history and that association was still significant in never smokers. Careful attention is needed for the general population who are potentially exposed to cadmium.

AB - Background: Most humans are exposed to environmental contaminants via inhalation. Various toxic inhalants cause lung damage with pathologic changes to the airway system. Lung function decline is an important cause of morbidity and mortality worldwide.Aim: To consider the potential burden of cadmium on pulmonary disease, this study examined the relationship between blood cadmium levels and airflow obstruction in a Korean general population.Subjects and methods: Data from the Korean National Health and Nutrition Examination Surveys from 2008-2011 were used. Male participants were selected who were older than 40 years, who had completed a reliable pulmonary function test and for who measurements of blood cadmium levels were available (n = 1974). The pulmonary function tests were undertaken and airflow obstruction was defined when forced vital capacity/forced expiratory volume in 1 second ratio < 0.7.Results: In an age-adjusted logistic regression model, blood cadmium levels correlated with the risk of obstructive airflow pattern in total participants as well as in smokers or never smokers. Further adjustment for BMI, current occupation and educational level did not attenuate these associations among total participants, smokers and never smokers (OR = 2.53, 95% CI = 1.83-3.50 in total; OR = 2.17, 95% CI = 1.55-3.02 in smokers; OR = 3.71, 95% CI = 1.48-9.33 in never smokers).Conclusions: In conclusion, blood cadmium level was associated with airflow obstruction independently of smoking history and that association was still significant in never smokers. Careful attention is needed for the general population who are potentially exposed to cadmium.

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