The association between blood lead level and clinical mental disorders in fifty thousand lead-exposed male workers

JinHa Yoon, Yeon Soon Ahn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of male workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00-F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 workers, there were 223 admission cases of mental disorders (F00-F99) during the follow-up period. The HR (95% CI) of total mental and behavioral disorders (F00-F99) was 1.63 (1.12-2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15-5.82) for mood (affective) disorders (F30-F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult male workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Affective Disorders
Volume190
DOIs
Publication statusPublished - 2016 Jan 15

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Mental Disorders
Mood Disorders
Confidence Intervals
Lead
International Classification of Diseases
Survival Analysis
Korea
Ambulatory Care Facilities
Proportional Hazards Models
Sample Size
Cohort Studies
Outpatients
Retrospective Studies
Research
Population

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

@article{56ccd76f0f134f1ebbf987229907c940,
title = "The association between blood lead level and clinical mental disorders in fifty thousand lead-exposed male workers",
abstract = "Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of male workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00-F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95{\%} confidence interval (95{\%} CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 workers, there were 223 admission cases of mental disorders (F00-F99) during the follow-up period. The HR (95{\%} CI) of total mental and behavioral disorders (F00-F99) was 1.63 (1.12-2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95{\%} CI) of the 4th quartile group was 2.59 (1.15-5.82) for mood (affective) disorders (F30-F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult male workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.",
author = "JinHa Yoon and Ahn, {Yeon Soon}",
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The association between blood lead level and clinical mental disorders in fifty thousand lead-exposed male workers. / Yoon, JinHa; Ahn, Yeon Soon.

In: Journal of Affective Disorders, Vol. 190, 15.01.2016, p. 41-46.

Research output: Contribution to journalArticle

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N2 - Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of male workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00-F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 workers, there were 223 admission cases of mental disorders (F00-F99) during the follow-up period. The HR (95% CI) of total mental and behavioral disorders (F00-F99) was 1.63 (1.12-2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15-5.82) for mood (affective) disorders (F30-F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult male workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.

AB - Background While there has been research into the relationship between blood lead (BPb) level and mental disorders, there have been few investigations that use clinically diagnosed mental disorders in the adult population with a retrospective cohort study design. Hence, our study investigated the association between BPb level and risk of clinically diagnosed mental disorders. Methods The data of male workers exposed to lead (Pb; n=54,788) were collected from annual Pb associated medical check-ups from 2000 to 2004 in Korea. The workers' hospital admission histories due to mental disorders (International Classification of Diseases, 10th revision, F00-F99) were used to identify clinically diagnosed mental disorders. After merging the data, the hazard ratio (HR) with a 95% confidence interval (95% CI) was calculated by survival analysis using the Cox proportional hazards model according to the quartile level of BPb (1st quartile<4.10 μg/dl, 2nd quartile<6.04 μg/dl, 3rd quartile<10.00 μg/dl, and 4th quartile≥10 μg/dl). Results In a total of 54,788 workers, there were 223 admission cases of mental disorders (F00-F99) during the follow-up period. The HR (95% CI) of total mental and behavioral disorders (F00-F99) was 1.63 (1.12-2.39) in the 4th quartile group compared to the HR of the 1st quartile group after adjusting for age. The HR (95% CI) of the 4th quartile group was 2.59 (1.15-5.82) for mood (affective) disorders (F30-F39). Limitation The hospital admission data, not outpatient data, were used for current study while almost affective disorder treated at outpatient clinic level. Conclusion Our study highlighted that Pb exposure can cause clinical mental disorders that require hospital admission in adult male workers. Our relatively large sample size strengthens the evidence of the association between BPb level and risk of clinically diagnosed mental disorders.

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