The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults

Mi Kyung Lee, Sang Hui Chu, Duk Chul Lee, Ki Yong An, Ji Hye Park, Dong Il Kim, Jiyoung Kim, Sunghyun Hong, Jee Aee Im, Ji Won Lee, Justin Y. Jeon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. Methods: Forty male and 20 female obese adults (mean age: 29.7±5.7y, mean BMI: 29.3±4.5kg/m2) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. Results: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9 ± 6.6 vs. 7.6 ± 5.3 μU/ml, p< 0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3 ± 1.5 vs. 1.6 ± 1.2, p< 0.001), chemerin (103.3 ± 20.7 vs. 96.5 ± 19.5. ng/ml, p< 0.001) and hs-CRP levels (1.3 ± 1.8 vs. 0.2 ± 0.2. mg/dl, p< 0.001) while it increased fasting pentraxin (PTX) 3 (0.6 ± 0.7 vs. 0.7 ± 0.4. ng/ml, p= 0.049) level. The δ chemerin levels correlated with δ insulin (r = 0.349, p= 0.024) and HOMA-IR (r = 0.333, p= 0.36) even after adjusting for age and gender. Conclusion: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalClinica Chimica Acta
Volume421
DOIs
Publication statusPublished - 2013 Jun 5

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Insulin Resistance
Life Style
Weight Loss
Young Adult
Homeostasis
Association reactions
Insulin
Intra-Abdominal Fat
Fats
Adiponectin
Fasting
Adipokines
Subcutaneous Fat
Adiposity
Biomarkers
Nutrition
Body Weight
Exercise
Diet

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lee, Mi Kyung ; Chu, Sang Hui ; Lee, Duk Chul ; An, Ki Yong ; Park, Ji Hye ; Kim, Dong Il ; Kim, Jiyoung ; Hong, Sunghyun ; Im, Jee Aee ; Lee, Ji Won ; Jeon, Justin Y. / The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults. In: Clinica Chimica Acta. 2013 ; Vol. 421. pp. 109-115.
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abstract = "Background: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. Methods: Forty male and 20 female obese adults (mean age: 29.7±5.7y, mean BMI: 29.3±4.5kg/m2) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. Results: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8{\%}, 15.3{\%} and 11.5{\%}, respectively. The lifestyle intervention further reduced fasting insulin (10.9 ± 6.6 vs. 7.6 ± 5.3 μU/ml, p< 0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3 ± 1.5 vs. 1.6 ± 1.2, p< 0.001), chemerin (103.3 ± 20.7 vs. 96.5 ± 19.5. ng/ml, p< 0.001) and hs-CRP levels (1.3 ± 1.8 vs. 0.2 ± 0.2. mg/dl, p< 0.001) while it increased fasting pentraxin (PTX) 3 (0.6 ± 0.7 vs. 0.7 ± 0.4. ng/ml, p= 0.049) level. The δ chemerin levels correlated with δ insulin (r = 0.349, p= 0.024) and HOMA-IR (r = 0.333, p= 0.36) even after adjusting for age and gender. Conclusion: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.",
author = "Lee, {Mi Kyung} and Chu, {Sang Hui} and Lee, {Duk Chul} and An, {Ki Yong} and Park, {Ji Hye} and Kim, {Dong Il} and Jiyoung Kim and Sunghyun Hong and Im, {Jee Aee} and Lee, {Ji Won} and Jeon, {Justin Y.}",
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The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults. / Lee, Mi Kyung; Chu, Sang Hui; Lee, Duk Chul; An, Ki Yong; Park, Ji Hye; Kim, Dong Il; Kim, Jiyoung; Hong, Sunghyun; Im, Jee Aee; Lee, Ji Won; Jeon, Justin Y.

In: Clinica Chimica Acta, Vol. 421, 05.06.2013, p. 109-115.

Research output: Contribution to journalArticle

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T1 - The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults

AU - Lee, Mi Kyung

AU - Chu, Sang Hui

AU - Lee, Duk Chul

AU - An, Ki Yong

AU - Park, Ji Hye

AU - Kim, Dong Il

AU - Kim, Jiyoung

AU - Hong, Sunghyun

AU - Im, Jee Aee

AU - Lee, Ji Won

AU - Jeon, Justin Y.

PY - 2013/6/5

Y1 - 2013/6/5

N2 - Background: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. Methods: Forty male and 20 female obese adults (mean age: 29.7±5.7y, mean BMI: 29.3±4.5kg/m2) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. Results: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9 ± 6.6 vs. 7.6 ± 5.3 μU/ml, p< 0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3 ± 1.5 vs. 1.6 ± 1.2, p< 0.001), chemerin (103.3 ± 20.7 vs. 96.5 ± 19.5. ng/ml, p< 0.001) and hs-CRP levels (1.3 ± 1.8 vs. 0.2 ± 0.2. mg/dl, p< 0.001) while it increased fasting pentraxin (PTX) 3 (0.6 ± 0.7 vs. 0.7 ± 0.4. ng/ml, p= 0.049) level. The δ chemerin levels correlated with δ insulin (r = 0.349, p= 0.024) and HOMA-IR (r = 0.333, p= 0.36) even after adjusting for age and gender. Conclusion: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.

AB - Background: Chemerin is a recently discovered adipocytokine, associated with adiposity and insulin sensitivity. The current study investigated the effects of lifestyle intervention on circulating chemerin level and its association with insulin resistance and adiponectin in human. Methods: Forty male and 20 female obese adults (mean age: 29.7±5.7y, mean BMI: 29.3±4.5kg/m2) completed an 8-week lifestyle intervention program, which consisted of a home-based diet and exercise program. Anthropometric measurements and biomarkers were assessed at the baseline and at the end of the study. Results: Eight weeks of lifestyle intervention reduced body weight, visceral fat and subcutaneous fat by 3.8%, 15.3% and 11.5%, respectively. The lifestyle intervention further reduced fasting insulin (10.9 ± 6.6 vs. 7.6 ± 5.3 μU/ml, p< 0.001) and homeostasis assessment of insulin resistance (HOMA-IR) (2.3 ± 1.5 vs. 1.6 ± 1.2, p< 0.001), chemerin (103.3 ± 20.7 vs. 96.5 ± 19.5. ng/ml, p< 0.001) and hs-CRP levels (1.3 ± 1.8 vs. 0.2 ± 0.2. mg/dl, p< 0.001) while it increased fasting pentraxin (PTX) 3 (0.6 ± 0.7 vs. 0.7 ± 0.4. ng/ml, p= 0.049) level. The δ chemerin levels correlated with δ insulin (r = 0.349, p= 0.024) and HOMA-IR (r = 0.333, p= 0.36) even after adjusting for age and gender. Conclusion: The lifestyle intervention reduced circulating chemerin levels independent of visceral fat mass and adiponectin. Chemerin levels are associated with insulin resistance at the baseline and after the lifestyle intervention.

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