The association between coronary calcification and adenomatous polyps of colon in Korean adults

Hong Bae Kim, Yongjae Lee, Jae Yong Shim, Hye Ree Lee

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3 Citations (Scopus)

Abstract

Background and objective: Adenomatous polyps of colon is a precancerous lesion. Many studies have shown that the adenomatous polyps of colon and cardiovascular disease share several common risk factors. This cross-sectional study aimed to investigate whether coronary calcification is associated with the adenomatous polyps of colon. Methods: Among 1637 Korean adults, we examined the association between coronary calcium score (CCS) as a measurement of coronary calcification and the presence of adenomatous polyps of colon via multi-detected row computed tomography (MDCT) and colonoscopy, respectively. CCS values were categorized as follows: 0, 1-17, 18-105, or. ≥. 106. The odds ratios (ORs) and 95% confidence intervals (CIs) for the presence of adenomatous polyps of colon were calculated across CCS groups. Results and conclusions: After adjusting for confounding variables, the adjusted ORs (95% CIs) for the presence of adenomatous polyps of colon in each of the four CCS groups were 1.00 (reference), 1.44 (0.91-2.33), 1.88 (1.15-3.01) and 3.61 (2.23-5.74). And higher CCS values were associated with multiple polyps (P≤. 0.001), villous histologic features or high-grade dysplasia (P=. 0.02), and advanced adenomatous polyps (P≤. 0.001). A higher level of CCS was found to be strongly and independently associated with the presence of adenomatous polyps of colon in Korean adults. This finding suggests that people at high risk for coronary atherosclerosis through MDCT should be considered for further evaluation of adenomatous polyps.

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalClinics and Research in Hepatology and Gastroenterology
Volume38
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Adenomatous Polyps
Colon
Calcium
Odds Ratio
Tomography
Confidence Intervals
Confounding Factors (Epidemiology)
Colonoscopy
Polyps
Coronary Artery Disease
Cardiovascular Diseases
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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title = "The association between coronary calcification and adenomatous polyps of colon in Korean adults",
abstract = "Background and objective: Adenomatous polyps of colon is a precancerous lesion. Many studies have shown that the adenomatous polyps of colon and cardiovascular disease share several common risk factors. This cross-sectional study aimed to investigate whether coronary calcification is associated with the adenomatous polyps of colon. Methods: Among 1637 Korean adults, we examined the association between coronary calcium score (CCS) as a measurement of coronary calcification and the presence of adenomatous polyps of colon via multi-detected row computed tomography (MDCT) and colonoscopy, respectively. CCS values were categorized as follows: 0, 1-17, 18-105, or. ≥. 106. The odds ratios (ORs) and 95{\%} confidence intervals (CIs) for the presence of adenomatous polyps of colon were calculated across CCS groups. Results and conclusions: After adjusting for confounding variables, the adjusted ORs (95{\%} CIs) for the presence of adenomatous polyps of colon in each of the four CCS groups were 1.00 (reference), 1.44 (0.91-2.33), 1.88 (1.15-3.01) and 3.61 (2.23-5.74). And higher CCS values were associated with multiple polyps (P≤. 0.001), villous histologic features or high-grade dysplasia (P=. 0.02), and advanced adenomatous polyps (P≤. 0.001). A higher level of CCS was found to be strongly and independently associated with the presence of adenomatous polyps of colon in Korean adults. This finding suggests that people at high risk for coronary atherosclerosis through MDCT should be considered for further evaluation of adenomatous polyps.",
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The association between coronary calcification and adenomatous polyps of colon in Korean adults. / Kim, Hong Bae; Lee, Yongjae; Shim, Jae Yong; Lee, Hye Ree.

In: Clinics and Research in Hepatology and Gastroenterology, Vol. 38, No. 5, 01.01.2014, p. 649-654.

Research output: Contribution to journalArticle

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T1 - The association between coronary calcification and adenomatous polyps of colon in Korean adults

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N2 - Background and objective: Adenomatous polyps of colon is a precancerous lesion. Many studies have shown that the adenomatous polyps of colon and cardiovascular disease share several common risk factors. This cross-sectional study aimed to investigate whether coronary calcification is associated with the adenomatous polyps of colon. Methods: Among 1637 Korean adults, we examined the association between coronary calcium score (CCS) as a measurement of coronary calcification and the presence of adenomatous polyps of colon via multi-detected row computed tomography (MDCT) and colonoscopy, respectively. CCS values were categorized as follows: 0, 1-17, 18-105, or. ≥. 106. The odds ratios (ORs) and 95% confidence intervals (CIs) for the presence of adenomatous polyps of colon were calculated across CCS groups. Results and conclusions: After adjusting for confounding variables, the adjusted ORs (95% CIs) for the presence of adenomatous polyps of colon in each of the four CCS groups were 1.00 (reference), 1.44 (0.91-2.33), 1.88 (1.15-3.01) and 3.61 (2.23-5.74). And higher CCS values were associated with multiple polyps (P≤. 0.001), villous histologic features or high-grade dysplasia (P=. 0.02), and advanced adenomatous polyps (P≤. 0.001). A higher level of CCS was found to be strongly and independently associated with the presence of adenomatous polyps of colon in Korean adults. This finding suggests that people at high risk for coronary atherosclerosis through MDCT should be considered for further evaluation of adenomatous polyps.

AB - Background and objective: Adenomatous polyps of colon is a precancerous lesion. Many studies have shown that the adenomatous polyps of colon and cardiovascular disease share several common risk factors. This cross-sectional study aimed to investigate whether coronary calcification is associated with the adenomatous polyps of colon. Methods: Among 1637 Korean adults, we examined the association between coronary calcium score (CCS) as a measurement of coronary calcification and the presence of adenomatous polyps of colon via multi-detected row computed tomography (MDCT) and colonoscopy, respectively. CCS values were categorized as follows: 0, 1-17, 18-105, or. ≥. 106. The odds ratios (ORs) and 95% confidence intervals (CIs) for the presence of adenomatous polyps of colon were calculated across CCS groups. Results and conclusions: After adjusting for confounding variables, the adjusted ORs (95% CIs) for the presence of adenomatous polyps of colon in each of the four CCS groups were 1.00 (reference), 1.44 (0.91-2.33), 1.88 (1.15-3.01) and 3.61 (2.23-5.74). And higher CCS values were associated with multiple polyps (P≤. 0.001), villous histologic features or high-grade dysplasia (P=. 0.02), and advanced adenomatous polyps (P≤. 0.001). A higher level of CCS was found to be strongly and independently associated with the presence of adenomatous polyps of colon in Korean adults. This finding suggests that people at high risk for coronary atherosclerosis through MDCT should be considered for further evaluation of adenomatous polyps.

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