The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

Hyunsung Park, Jae Jun Park, Yoo Mi Park, Su Jung Baik, Hyun Ju Lee, Da Hyun Jung, Jie-Hyun Kim, Young Hoon Youn, HyoJin Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. Methods: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H. pylori immunoglobulin G or rapid urease test, if the anti-H. pylori immunoglobulin G was in the borderline range. Results: Among the 19 337 patients who were included, 56.2% and 3.4% were positive for H. pylori and ACN, respectively. Helicobacter pylori infection independently increased the risk of ACN in patients aged <50 years (odds ratio [OR], 1.602; 95% confidence intervals [CI], 1.194-2.150) but not in patients aged ≥50 years (OR, 1.046; 95% CI, 0.863-1.268). The positive association between H. pylori infection and ACN was affected by smoking history. When stratified by age and smoking history, H. pylori infection conferred an increased risk of ACN in patients aged <50 years with a history of smoking (OR, 1.926; 95% CI, 1.336-2.775) but not in the other 3 groups (3-way interaction test P =.023). Among patients aged <50 years with ACN, ACN in the left colon was found more frequently in patients with H. pylori infection and a history of smoking than in those without (69.3% vs 54.4%, respectively; P =.031). Conclusions: Helicobacter pylori infection confers an increased risk of ACN, but the association may differ according to age and smoking history.

Original languageEnglish
Article numbere12477
JournalHelicobacter
Volume23
Issue number3
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Helicobacter Infections
Helicobacter pylori
Pylorus
Smoking
Neoplasms
Infection
History
Odds Ratio
Confidence Intervals
Immunoglobulin G
Urease
Colonoscopy
Colon
Age Groups
Health

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Infectious Diseases

Cite this

Park, Hyunsung ; Park, Jae Jun ; Park, Yoo Mi ; Baik, Su Jung ; Lee, Hyun Ju ; Jung, Da Hyun ; Kim, Jie-Hyun ; Youn, Young Hoon ; Park, HyoJin. / The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking. In: Helicobacter. 2018 ; Vol. 23, No. 3.
@article{44b4b8d3fb6542d9ade3f3c35db8b15c,
title = "The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking",
abstract = "Background: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. Methods: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H. pylori immunoglobulin G or rapid urease test, if the anti-H. pylori immunoglobulin G was in the borderline range. Results: Among the 19 337 patients who were included, 56.2{\%} and 3.4{\%} were positive for H. pylori and ACN, respectively. Helicobacter pylori infection independently increased the risk of ACN in patients aged <50 years (odds ratio [OR], 1.602; 95{\%} confidence intervals [CI], 1.194-2.150) but not in patients aged ≥50 years (OR, 1.046; 95{\%} CI, 0.863-1.268). The positive association between H. pylori infection and ACN was affected by smoking history. When stratified by age and smoking history, H. pylori infection conferred an increased risk of ACN in patients aged <50 years with a history of smoking (OR, 1.926; 95{\%} CI, 1.336-2.775) but not in the other 3 groups (3-way interaction test P =.023). Among patients aged <50 years with ACN, ACN in the left colon was found more frequently in patients with H. pylori infection and a history of smoking than in those without (69.3{\%} vs 54.4{\%}, respectively; P =.031). Conclusions: Helicobacter pylori infection confers an increased risk of ACN, but the association may differ according to age and smoking history.",
author = "Hyunsung Park and Park, {Jae Jun} and Park, {Yoo Mi} and Baik, {Su Jung} and Lee, {Hyun Ju} and Jung, {Da Hyun} and Jie-Hyun Kim and Youn, {Young Hoon} and HyoJin Park",
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month = "6",
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doi = "10.1111/hel.12477",
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The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking. / Park, Hyunsung; Park, Jae Jun; Park, Yoo Mi; Baik, Su Jung; Lee, Hyun Ju; Jung, Da Hyun; Kim, Jie-Hyun; Youn, Young Hoon; Park, HyoJin.

In: Helicobacter, Vol. 23, No. 3, e12477, 01.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

AU - Park, Hyunsung

AU - Park, Jae Jun

AU - Park, Yoo Mi

AU - Baik, Su Jung

AU - Lee, Hyun Ju

AU - Jung, Da Hyun

AU - Kim, Jie-Hyun

AU - Youn, Young Hoon

AU - Park, HyoJin

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. Methods: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H. pylori immunoglobulin G or rapid urease test, if the anti-H. pylori immunoglobulin G was in the borderline range. Results: Among the 19 337 patients who were included, 56.2% and 3.4% were positive for H. pylori and ACN, respectively. Helicobacter pylori infection independently increased the risk of ACN in patients aged <50 years (odds ratio [OR], 1.602; 95% confidence intervals [CI], 1.194-2.150) but not in patients aged ≥50 years (OR, 1.046; 95% CI, 0.863-1.268). The positive association between H. pylori infection and ACN was affected by smoking history. When stratified by age and smoking history, H. pylori infection conferred an increased risk of ACN in patients aged <50 years with a history of smoking (OR, 1.926; 95% CI, 1.336-2.775) but not in the other 3 groups (3-way interaction test P =.023). Among patients aged <50 years with ACN, ACN in the left colon was found more frequently in patients with H. pylori infection and a history of smoking than in those without (69.3% vs 54.4%, respectively; P =.031). Conclusions: Helicobacter pylori infection confers an increased risk of ACN, but the association may differ according to age and smoking history.

AB - Background: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. Methods: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H. pylori immunoglobulin G or rapid urease test, if the anti-H. pylori immunoglobulin G was in the borderline range. Results: Among the 19 337 patients who were included, 56.2% and 3.4% were positive for H. pylori and ACN, respectively. Helicobacter pylori infection independently increased the risk of ACN in patients aged <50 years (odds ratio [OR], 1.602; 95% confidence intervals [CI], 1.194-2.150) but not in patients aged ≥50 years (OR, 1.046; 95% CI, 0.863-1.268). The positive association between H. pylori infection and ACN was affected by smoking history. When stratified by age and smoking history, H. pylori infection conferred an increased risk of ACN in patients aged <50 years with a history of smoking (OR, 1.926; 95% CI, 1.336-2.775) but not in the other 3 groups (3-way interaction test P =.023). Among patients aged <50 years with ACN, ACN in the left colon was found more frequently in patients with H. pylori infection and a history of smoking than in those without (69.3% vs 54.4%, respectively; P =.031). Conclusions: Helicobacter pylori infection confers an increased risk of ACN, but the association may differ according to age and smoking history.

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