The association between low level of high-density lipoprotein cholesterol and mood disorder using time-dependent analysis

Seung Ju Kim, Kyu Tae Han, Suk Yong Jang, Eun Cheol Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Although many studies have identified factors associated with mood disorder, the association between high-density lipoprotein cholesterol (HDL-C) and mood disorder is still controversial. The aim of our study was to evaluate the association between low HDL-C and onset of mood disorder in Korea based on different cut-off levels. Methods We used National Health Examinations Service cohort data from 2009 to 2013. We used time-dependent Cox regression analysis to evaluate the association between low level of HDL-C and onset of mood disorder. Hazard ratios (HRs) for onset of mood disorder were estimated for 1- to 2-year time intervals, starting at the first health examination and accounting for the duration until the next health examination. Results A total of 400,803 participants (male: 220,573; female: 180,230) were included in our study. A total of 4576 (2.07%) males and 7598 (4.22%) females developed mood disorder. Based on dyslipidemia (< 40 mg/dL), low level of HDL-C was associated with the risk of mood disorder in both male and female, however, only females showed statistically significant (HR: 1.097, 95% CI: 1.012–1.189). Based on quartile-based approach, females with low levels of HDL-C (< 47 mg/dL) and males with high levels of HDL-C (≥ 59 mg/dL) were associated with subsequent risk of mood disorder. Conclusions Our findings suggest that level of HDL-C is associated with potential risk factors in mood disorder. However, a flexible threshold value in HDL-C level would be needed to evaluate the subsequent risk of mood disorder. Thus, further studies are needed to help improve the mental health in susceptible individuals.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalJournal of affective disorders
Volume225
DOIs
Publication statusPublished - 2018 Jan 1

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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