Abstract
Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.
| Original language | English |
|---|---|
| Pages (from-to) | 1430-1437 |
| Number of pages | 8 |
| Journal | Clinica Chimica Acta |
| Volume | 413 |
| Issue number | 19-20 |
| DOIs | |
| Publication status | Published - 2012 Oct 9 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical
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The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention. / Chu, Sang Hui; Park, Ji Hye; Lee, Mi Kyung; Jekal, Yoonsuk; Ahn, Ki Yong; Chung, Jae Youn; Lee, Dong Hoon; Kim, Eun Sung; Naruse, Masayo; Im, Jee Aee; Kong, Deok; Chung, Choon Hee; Lee, Ji Won; Chung, Kyongmee; Kim, Young Bum; Jeon, Justin Y.
In: Clinica Chimica Acta, Vol. 413, No. 19-20, 09.10.2012, p. 1430-1437.Research output: Contribution to journal › Article
TY - JOUR
T1 - The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention
AU - Chu, Sang Hui
AU - Park, Ji Hye
AU - Lee, Mi Kyung
AU - Jekal, Yoonsuk
AU - Ahn, Ki Yong
AU - Chung, Jae Youn
AU - Lee, Dong Hoon
AU - Kim, Eun Sung
AU - Naruse, Masayo
AU - Im, Jee Aee
AU - Kong, Deok
AU - Chung, Choon Hee
AU - Lee, Ji Won
AU - Chung, Kyongmee
AU - Kim, Young Bum
AU - Jeon, Justin Y.
PY - 2012/10/9
Y1 - 2012/10/9
N2 - Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.
AB - Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.
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U2 - 10.1016/j.cca.2012.06.002
DO - 10.1016/j.cca.2012.06.002
M3 - Article
VL - 413
SP - 1430
EP - 1437
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 19-20
ER -