The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention

Sang Hui Chu, Ji Hye Park, Mi Kyung Lee, Yoonsuk Jekal, Ki Yong Ahn, Jae Youn Chung, Dong Hoon Lee, Eun Sung Kim, Masayo Naruse, Jee Aee Im, Deok Kong, Choon Hee Chung, Ji Won Lee, Kyongmee Chung, Young Bum Kim, Justin Y. Jeon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.

Original languageEnglish
Pages (from-to)1430-1437
Number of pages8
JournalClinica Chimica Acta
Volume413
Issue number19-20
DOIs
Publication statusPublished - 2012 Oct 9

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Insulin Resistance
Exercise
Insulin
Homeostasis
Fasting
PTX3 protein
Eating

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Chu, Sang Hui ; Park, Ji Hye ; Lee, Mi Kyung ; Jekal, Yoonsuk ; Ahn, Ki Yong ; Chung, Jae Youn ; Lee, Dong Hoon ; Kim, Eun Sung ; Naruse, Masayo ; Im, Jee Aee ; Kong, Deok ; Chung, Choon Hee ; Lee, Ji Won ; Chung, Kyongmee ; Kim, Young Bum ; Jeon, Justin Y. / The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention. In: Clinica Chimica Acta. 2012 ; Vol. 413, No. 19-20. pp. 1430-1437.
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title = "The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention",
abstract = "Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.",
author = "Chu, {Sang Hui} and Park, {Ji Hye} and Lee, {Mi Kyung} and Yoonsuk Jekal and Ahn, {Ki Yong} and Chung, {Jae Youn} and Lee, {Dong Hoon} and Kim, {Eun Sung} and Masayo Naruse and Im, {Jee Aee} and Deok Kong and Chung, {Choon Hee} and Lee, {Ji Won} and Kyongmee Chung and Kim, {Young Bum} and Jeon, {Justin Y.}",
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Chu, SH, Park, JH, Lee, MK, Jekal, Y, Ahn, KY, Chung, JY, Lee, DH, Kim, ES, Naruse, M, Im, JA, Kong, D, Chung, CH, Lee, JW, Chung, K, Kim, YB & Jeon, JY 2012, 'The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention', Clinica Chimica Acta, vol. 413, no. 19-20, pp. 1430-1437. https://doi.org/10.1016/j.cca.2012.06.002

The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention. / Chu, Sang Hui; Park, Ji Hye; Lee, Mi Kyung; Jekal, Yoonsuk; Ahn, Ki Yong; Chung, Jae Youn; Lee, Dong Hoon; Kim, Eun Sung; Naruse, Masayo; Im, Jee Aee; Kong, Deok; Chung, Choon Hee; Lee, Ji Won; Chung, Kyongmee; Kim, Young Bum; Jeon, Justin Y.

In: Clinica Chimica Acta, Vol. 413, No. 19-20, 09.10.2012, p. 1430-1437.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention

AU - Chu, Sang Hui

AU - Park, Ji Hye

AU - Lee, Mi Kyung

AU - Jekal, Yoonsuk

AU - Ahn, Ki Yong

AU - Chung, Jae Youn

AU - Lee, Dong Hoon

AU - Kim, Eun Sung

AU - Naruse, Masayo

AU - Im, Jee Aee

AU - Kong, Deok

AU - Chung, Choon Hee

AU - Lee, Ji Won

AU - Chung, Kyongmee

AU - Kim, Young Bum

AU - Jeon, Justin Y.

PY - 2012/10/9

Y1 - 2012/10/9

N2 - Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.

AB - Background: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. Methods: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2kg/m 2 ) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34kcal/day) and food intake (1882±68.8kcal/day) were tightly controlled. Results: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33 ± 1.3 vs -1.46 ± 0.70, p=0.004). Conclusion: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.

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U2 - 10.1016/j.cca.2012.06.002

DO - 10.1016/j.cca.2012.06.002

M3 - Article

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SP - 1430

EP - 1437

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 19-20

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