TY - JOUR
T1 - The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea
T2 - The ARIRANG study
AU - Ahn, Min Soo
AU - Koh, Sang Baek
AU - Kim, Jang Young
AU - Yoon, Jin Ha
AU - Sung, Joong Kyung
AU - Youn, Young Jin
AU - Yoo, Byung Su
AU - Lee, Seung Hwan
AU - Yoon, Junghan
AU - Eom, Aeyong
AU - Park, Jong Ku
AU - Choe, Kyung Hoon
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/3
Y1 - 2011/3
N2 - Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.
AB - Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.
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U2 - 10.1007/s13273-011-0005-1
DO - 10.1007/s13273-011-0005-1
M3 - Article
AN - SCOPUS:79960089610
VL - 7
SP - 33
EP - 38
JO - Molecular and Cellular Toxicology
JF - Molecular and Cellular Toxicology
SN - 1738-642X
IS - 1
ER -