The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea: The ARIRANG study

Min Soo Ahn, Sang Baek Koh, Jang Young Kim, Jin Ha Yoon, Joong Kyung Sung, Young Jin Youn, Byung Su Yoo, Seung Hwan Lee, Junghan Yoon, Aeyong Eom, Jong Ku Park, Kyung Hoon Choe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalMolecular and Cellular Toxicology
Volume7
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1

Fingerprint

Carotid Intima-Media Thickness
Adiponectin
Korea
Serum
Blood Pressure
Atherosclerosis
Blood pressure
Insulin
Preexisting Condition Coverage
Waist Circumference
C-Reactive Protein
Sample Size
LDL Cholesterol
HDL Cholesterol
Radioimmunoassay
Insulin Resistance
Healthy Volunteers
Triglycerides
Body Mass Index
Homeostasis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea: The ARIRANG study",
abstract = "Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.",
author = "Ahn, {Min Soo} and Koh, {Sang Baek} and Kim, {Jang Young} and Yoon, {Jin Ha} and Sung, {Joong Kyung} and Youn, {Young Jin} and Yoo, {Byung Su} and Lee, {Seung Hwan} and Junghan Yoon and Aeyong Eom and Park, {Jong Ku} and Choe, {Kyung Hoon}",
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The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea : The ARIRANG study. / Ahn, Min Soo; Koh, Sang Baek; Kim, Jang Young; Yoon, Jin Ha; Sung, Joong Kyung; Youn, Young Jin; Yoo, Byung Su; Lee, Seung Hwan; Yoon, Junghan; Eom, Aeyong; Park, Jong Ku; Choe, Kyung Hoon.

In: Molecular and Cellular Toxicology, Vol. 7, No. 1, 01.03.2011, p. 33-38.

Research output: Contribution to journalArticle

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T1 - The association between serum adiponectin and carotid intima media thickness in community based cohort in Korea

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AU - Ahn, Min Soo

AU - Koh, Sang Baek

AU - Kim, Jang Young

AU - Yoon, Jin Ha

AU - Sung, Joong Kyung

AU - Youn, Young Jin

AU - Yoo, Byung Su

AU - Lee, Seung Hwan

AU - Yoon, Junghan

AU - Eom, Aeyong

AU - Park, Jong Ku

AU - Choe, Kyung Hoon

PY - 2011/3/1

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N2 - Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.

AB - Growing body of evidence suggests an association between circulating adiponectin and the development of atherosclerosis. However most of these studies have been performed with healthy subjects with relatively small sample size or patients with preexisting cardiovascular diseases. The results obtained are inconstant for an independent association between adiponectin and subclinical atherosclerosis. We aimed to evaluate the association between circulating adiponectin and carotid intima media thickness (CIMT) in a large sample of individuals from the community. We performed a non-diabetic community based cohort study conducted on a healthy Korean adults (age>40 years) population. The serum adiponectin concentrations were measured by a radioimmunoassay. The mean adiponectin level was significantly lower in subjects with high CIMT defined by >0.9 mm than those with low CIMT (9.18 vs. 10.44 μg/mL, P=0.03). The adiponectin level was correlated negatively with waist circumference (r=-0.27), body mass index (r=-0.21), systolic blood pressure (r=-0.11), diastolic blood pressure (r=-0.10), triglyceride (r=- 0.30), LDL-cholesterol (r=-0.02), glucose (r=-0.16), insulin (r=-0.17), homeostasis assessment-insulin resistance (r=-0.23) and C-reactive protein (r=- 0.11), and correlated positively with HDL cholesterol (r=0.30) (all P>0.05). Adiponectin was significantly associated with CIMT independently of age, sex, and all metabolic risk factors (R2=0.14, P=0.04). In conclusion, serum adiponectin levels are independently associated with CIMT as a surrogate of subclinical atherosclerosis in a non-diabetic community based cohort.

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