The association between serum vitamin D level and immunoglobulin E in Korean adolescents

Ju Wan Kang, Jeong Hong Kim, Joo Heon Yoon, Chang-Hoon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents. Methods: A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables. Results: Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R) = 0.126, p = 0.016; R = 0.152, p = 0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95% confidence interval (CI): 0.59-20.31; B: 1.06, 95% CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization. Conclusions: Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume78
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Vitamin D
Immunoglobulin E
Dermatophagoides farinae
Serum
Regression Analysis
Confidence Intervals
Confounding Factors (Epidemiology)
Nutrition Surveys
Korea
Linear Models
Body Mass Index
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology

Cite this

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title = "The association between serum vitamin D level and immunoglobulin E in Korean adolescents",
abstract = "Objective: Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents. Methods: A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables. Results: Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R) = 0.126, p = 0.016; R = 0.152, p = 0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95{\%} confidence interval (CI): 0.59-20.31; B: 1.06, 95{\%} CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization. Conclusions: Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.",
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The association between serum vitamin D level and immunoglobulin E in Korean adolescents. / Kang, Ju Wan; Kim, Jeong Hong; Yoon, Joo Heon; Kim, Chang-Hoon.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 78, No. 5, 01.01.2014, p. 817-820.

Research output: Contribution to journalArticle

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AU - Kang, Ju Wan

AU - Kim, Jeong Hong

AU - Yoon, Joo Heon

AU - Kim, Chang-Hoon

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N2 - Objective: Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents. Methods: A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables. Results: Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R) = 0.126, p = 0.016; R = 0.152, p = 0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95% confidence interval (CI): 0.59-20.31; B: 1.06, 95% CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization. Conclusions: Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.

AB - Objective: Vitamin D has immune modulatory functions, and thus its relationship with allergic disease has been evaluated in a number of studies. However, no concrete link between serum IgE level and vitamin D has been established. Thus, the purpose of study was to confirm the association of serum vitamin D level with the serum IgE (total and Dematophagoides farinae specific IgE) in Korean adolescents. Methods: A total of 365 subjects between 10 and 18 years of age were enrolled through the Korea National Health and Nutrition Examination Survey (KNHANES). Serum levels of vitamin D, total IgE, and Dermatophagoides farinae (Df) specific IgE were measured, and data for potential confounding variables were collected. Multivariate regression analyses were used to determine the independent effects of these variables. Results: Levels of both total and Df specific IgE were positively correlated with serum concentration of vitamin D (Spearman's rho (R) = 0.126, p = 0.016; R = 0.152, p = 0.004, respectively). These results were confirmed by multivariate linear regression analysis after adjusting for sex, age, and body mass index (coefficient (B): 10.45 95% confidence interval (CI): 0.59-20.31; B: 1.06, 95% CI: 0.31-1.80, respectively). And, the association between serum vitamin D and IgE showed the different results depending on the presence or absence of Df sensitization. Conclusions: Serum concentration of vitamin D was positively associated with levels of both total IgE and Df-specific IgE in Korean adolescents.

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