The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease

Results from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD)

Eunjeong Kang, Joongyub Lee, Hyo Jin Kim, Miyeun Han, Woo Wan Kim, Kyu Beck Lee, Suah Sung, TaeHyun Yoo, Wookyung Chung, Curie Ahn, Kook Hwan Oh

Research output: Contribution to journalArticle

Abstract

Background: Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear. Methods: Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at http://www.clinicaltrials.gov). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height 2.7 ≥ 47 g/m 2.7 in female and ≥ 50 g/m 2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates. Results: A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2% were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95% CI 1.069-2.063, P = 0.018; completed high school, adjusted OR 1.150, 95% confidence interval [CI] 0.834-1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95% CI 0.866-1.748, P = 0.247; < $1500, adjusted OR 1.471, 95% CI 1.002-2.158, P = 0.049; > $4500; reference). Conclusions: In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.

Original languageEnglish
Article number203
JournalBMC Nephrology
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Aug 16

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Left Ventricular Hypertrophy
Chronic Renal Insufficiency
Social Class
Cohort Studies
Body Mass Index
Cardiovascular Diseases
Exercise
Blood Pressure
Education
Mortality
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kang, Eunjeong ; Lee, Joongyub ; Kim, Hyo Jin ; Han, Miyeun ; Kim, Woo Wan ; Lee, Kyu Beck ; Sung, Suah ; Yoo, TaeHyun ; Chung, Wookyung ; Ahn, Curie ; Oh, Kook Hwan. / The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease : Results from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD). In: BMC Nephrology. 2018 ; Vol. 19, No. 1.
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abstract = "Background: Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear. Methods: Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at http://www.clinicaltrials.gov). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height 2.7 ≥ 47 g/m 2.7 in female and ≥ 50 g/m 2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates. Results: A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2{\%} were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95{\%} CI 1.069-2.063, P = 0.018; completed high school, adjusted OR 1.150, 95{\%} confidence interval [CI] 0.834-1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95{\%} CI 0.866-1.748, P = 0.247; < $1500, adjusted OR 1.471, 95{\%} CI 1.002-2.158, P = 0.049; > $4500; reference). Conclusions: In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.",
author = "Eunjeong Kang and Joongyub Lee and Kim, {Hyo Jin} and Miyeun Han and Kim, {Woo Wan} and Lee, {Kyu Beck} and Suah Sung and TaeHyun Yoo and Wookyung Chung and Curie Ahn and Oh, {Kook Hwan}",
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The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease : Results from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD). / Kang, Eunjeong; Lee, Joongyub; Kim, Hyo Jin; Han, Miyeun; Kim, Woo Wan; Lee, Kyu Beck; Sung, Suah; Yoo, TaeHyun; Chung, Wookyung; Ahn, Curie; Oh, Kook Hwan.

In: BMC Nephrology, Vol. 19, No. 1, 203, 16.08.2018.

Research output: Contribution to journalArticle

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T1 - The association between socioeconomic disparities and left ventricular hypertrophy in chronic kidney disease

T2 - Results from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD)

AU - Kang, Eunjeong

AU - Lee, Joongyub

AU - Kim, Hyo Jin

AU - Han, Miyeun

AU - Kim, Woo Wan

AU - Lee, Kyu Beck

AU - Sung, Suah

AU - Yoo, TaeHyun

AU - Chung, Wookyung

AU - Ahn, Curie

AU - Oh, Kook Hwan

PY - 2018/8/16

Y1 - 2018/8/16

N2 - Background: Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear. Methods: Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at http://www.clinicaltrials.gov). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height 2.7 ≥ 47 g/m 2.7 in female and ≥ 50 g/m 2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates. Results: A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2% were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95% CI 1.069-2.063, P = 0.018; completed high school, adjusted OR 1.150, 95% confidence interval [CI] 0.834-1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95% CI 0.866-1.748, P = 0.247; < $1500, adjusted OR 1.471, 95% CI 1.002-2.158, P = 0.049; > $4500; reference). Conclusions: In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.

AB - Background: Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remains unclear. Methods: Data were collected from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD, NCT01630486 at http://www.clinicaltrials.gov). Subjects with CKD and aged ≥50 were included. SES was characterized based on monthly income and educational attainment, each of which was divided into three strata. LVH was defined as LV mass/height 2.7 ≥ 47 g/m 2.7 in female and ≥ 50 g/m 2.7 in male. Age, sex, diabetes, CKD stage, body mass index, blood pressure and physical activity were included as covariates. Results: A total of 1361 patients were included. Mean age was 60.9 ± 6.9 years, and 63.2% were men. Higher education level was associated with higher monthly income (P for trend < 0.001). The lowest education level was independently associated with LVH (lower than high school, adjusted odds ratio [OR] 1.485, 95% CI 1.069-2.063, P = 0.018; completed high school, adjusted OR 1.150, 95% confidence interval [CI] 0.834-1.584, P = 0.394; highest education level as the reference). Monthly income level was marginally associated with LVH after adjusting for covariates ($1500-4500, adjusted OR 1.230, 95% CI 0.866-1.748, P = 0.247; < $1500, adjusted OR 1.471, 95% CI 1.002-2.158, P = 0.049; > $4500; reference). Conclusions: In the CKD population, lower SES, defined by educational attainment and low income level exhibited a significant association with LVH, respectively. Longitudinal follow-up will reveal whether lower SES is associated with poor CKD outcomes.

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