The association between soluble klotho and cardiovascular parameters in chronic kidney disease

Results from the KNOW-CKD study

Hyo Jin Kim, Eunjeong Kang, Yun Kyu Oh, Yeong Hoon Kim, SeungHyeok Han, TaeHyun Yoo, Dong Wan Chae, Joongyub Lee, Curie Ahn, Kook Hwan Oh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods: We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results: Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m 2 . The median serum klotho level was 536 (interquartile range [IQR]: 420-667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β - 0.04; 95% CI [confidence interval] -0.004, - 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration: This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions: Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.

Original languageEnglish
Article number51
JournalBMC Nephrology
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Mar 5

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Chronic Renal Insufficiency
Serum
Pulse Wave Analysis
Vascular Stiffness
Ankle
Linear Models
Arm
Confidence Intervals
Left Ventricular Hypertrophy
Glomerular Filtration Rate
Minerals
Cohort Studies
Cardiovascular Diseases
Biomarkers
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kim, Hyo Jin ; Kang, Eunjeong ; Oh, Yun Kyu ; Kim, Yeong Hoon ; Han, SeungHyeok ; Yoo, TaeHyun ; Chae, Dong Wan ; Lee, Joongyub ; Ahn, Curie ; Oh, Kook Hwan. / The association between soluble klotho and cardiovascular parameters in chronic kidney disease : Results from the KNOW-CKD study. In: BMC Nephrology. 2018 ; Vol. 19, No. 1.
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title = "The association between soluble klotho and cardiovascular parameters in chronic kidney disease: Results from the KNOW-CKD study",
abstract = "Background: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods: We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results: Patients were 53.6 ± 12.2 years old and 61.1{\%} were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m 2 . The median serum klotho level was 536 (interquartile range [IQR]: 420-667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β - 0.04; 95{\%} CI [confidence interval] -0.004, - 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95{\%} CI -0.04, 0.05; P = 0.876). Trial registration: This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions: Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.",
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The association between soluble klotho and cardiovascular parameters in chronic kidney disease : Results from the KNOW-CKD study. / Kim, Hyo Jin; Kang, Eunjeong; Oh, Yun Kyu; Kim, Yeong Hoon; Han, SeungHyeok; Yoo, TaeHyun; Chae, Dong Wan; Lee, Joongyub; Ahn, Curie; Oh, Kook Hwan.

In: BMC Nephrology, Vol. 19, No. 1, 51, 05.03.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between soluble klotho and cardiovascular parameters in chronic kidney disease

T2 - Results from the KNOW-CKD study

AU - Kim, Hyo Jin

AU - Kang, Eunjeong

AU - Oh, Yun Kyu

AU - Kim, Yeong Hoon

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Chae, Dong Wan

AU - Lee, Joongyub

AU - Ahn, Curie

AU - Oh, Kook Hwan

PY - 2018/3/5

Y1 - 2018/3/5

N2 - Background: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods: We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results: Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m 2 . The median serum klotho level was 536 (interquartile range [IQR]: 420-667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β - 0.04; 95% CI [confidence interval] -0.004, - 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration: This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions: Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.

AB - Background: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. Methods: We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters. Results: Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m 2 . The median serum klotho level was 536 (interquartile range [IQR]: 420-667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β - 0.04; 95% CI [confidence interval] -0.004, - 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876). Trial registration: This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486). Conclusions: Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.

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