The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population

H. T. Kang; J. H. Yoon; J. Y. Kim; S. K. Ahn; J. A. Linton; S. B. Koh; J. K. Kim

doi:10.1016/j.numecd.2011.01.013

The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population

H. T. Kang, J. H. Yoon, J. Y. Kim, S. K. Ahn, J. A. Linton, S. B. Koh, J. K. Kim

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Abstract

Background and aims: This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population. Methods and results: This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile. Conclusion: The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive.

Original language	English
Pages (from-to)	1054-1060
Number of pages	7
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	22
Issue number	12
DOIs	https://doi.org/10.1016/j.numecd.2011.01.013
Publication status	Published - 2012 Dec

Bibliographical note

Funding Information:
We thank all members in the Cohort study at Wonju Christian Hospital for their helpful discussion and comments. This study was supported, in part, by a grant from the Korean Centers for Disease Control and Prevention (Research Serial Numbers: 2005-E71013-00 , 2006-E71002-00 and 2007-E71013-00 ).

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.numecd.2011.01.013

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title = "The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population",

abstract = "Background and aims: This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population. Methods and results: This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile. Conclusion: The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive.",

author = "Kang, {H. T.} and Yoon, {J. H.} and Kim, {J. Y.} and Ahn, {S. K.} and Linton, {J. A.} and Koh, {S. B.} and Kim, {J. K.}",

note = "Funding Information: We thank all members in the Cohort study at Wonju Christian Hospital for their helpful discussion and comments. This study was supported, in part, by a grant from the Korean Centers for Disease Control and Prevention (Research Serial Numbers: 2005-E71013-00 , 2006-E71002-00 and 2007-E71013-00 ).",

year = "2012",

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doi = "10.1016/j.numecd.2011.01.013",

language = "English",

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T1 - The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population

AU - Kang, H. T.

AU - Yoon, J. H.

AU - Kim, J. Y.

AU - Ahn, S. K.

AU - Linton, J. A.

AU - Koh, S. B.

AU - Kim, J. K.

N1 - Funding Information: We thank all members in the Cohort study at Wonju Christian Hospital for their helpful discussion and comments. This study was supported, in part, by a grant from the Korean Centers for Disease Control and Prevention (Research Serial Numbers: 2005-E71013-00 , 2006-E71002-00 and 2007-E71013-00 ).

PY - 2012/12

Y1 - 2012/12

N2 - Background and aims: This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population. Methods and results: This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile. Conclusion: The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive.

AB - Background and aims: This study aimed to examine the association between an increased ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) and insulin resistance as well as to investigate the interactive effect of TG/HDL-C and waist circumference on insulin resistance in a rural Korean population. Methods and results: This study, employing a cross-sectional design, included 8411 participants from the Korean Genomic Rural Cohort Study. Levels of fasting insulin, lipid profiles and anthropometric data were assessed for all participants. Insulin resistance was defined as a value greater than the 75th percentile on the homeostasis model assessment of insulin resistance (HOMA-IR). The TG/HDL-C ratio was positively correlated with waist circumference, total cholesterol, low-density lipoprotein cholesterol (LDL-C), TG and HOMA-IR, and negatively correlated with HDL-C when the calculations were controlled for gender. In comparison with the lowest quartile group of TG/HDL-C (≤1.92 in men, ≤1.63 in women), the odds ratios (ORs) (95% confidence interval) for insulin resistance in the highest quartile group of TG/HDL-C (>4.90 in men, >3.93 in women) were 2.33 (1.72-3.16) in men and 2.16 (1.73-2.71) in women, after adjusting for multiple covariates including waist circumference. Following stratification of waist circumference into quartiles, the effect of TG/HDL-C on insulin resistance remained significant irrespective of the waist circumference quartile. Conclusion: The TG/HDL-C ratio was linearly associated with insulin resistance in a rural Korean cohort independently of waist circumference in both genders, albeit not interactive.

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JO - Nutrition, Metabolism and Cardiovascular Diseases

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The association between the ratio of triglyceride to HDL-C and insulin resistance according to waist circumference in a rural Korean population

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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