The association of family history of premature cardiovascular disease or diabetes mellitus on the occurrence of gestational hypertensive disease and diabetes

Dong Ju Choi, Chang Hwan Yoon, Heesun Lee, So Yeon Ahn, Kyung Joon Oh, Hyun Young Park, Hea Young Lee, Myeong Chan Cho, Ick Mo Chung, Mi Seung Shin, Sung Ji Park, Chi Young Shim, Seong Woo Han, In Ho Chae

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. Methods: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual. Results: In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95% CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95% CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86-3.86; 1.84, 95% CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM. Conclusions: The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy.

Original languageEnglish
Article numbere0167528
JournalPloS one
Volume11
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

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cultural heritage
gestational diabetes
Medical problems
diabetes mellitus
Gestational Diabetes
cardiovascular diseases
diabetes
Diabetes Mellitus
Cardiovascular Diseases
pregnancy
Pregnancy
risk factors
nurses
Reproductive History
Nurses
Infertility
Chemical vapor deposition
hypertension
questionnaires
Hypertension

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Choi, Dong Ju ; Yoon, Chang Hwan ; Lee, Heesun ; Ahn, So Yeon ; Oh, Kyung Joon ; Park, Hyun Young ; Lee, Hea Young ; Cho, Myeong Chan ; Chung, Ick Mo ; Shin, Mi Seung ; Park, Sung Ji ; Shim, Chi Young ; Han, Seong Woo ; Chae, In Ho. / The association of family history of premature cardiovascular disease or diabetes mellitus on the occurrence of gestational hypertensive disease and diabetes. In: PloS one. 2016 ; Vol. 11, No. 12.
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abstract = "Background: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. Methods: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual. Results: In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3{\%}) experienced GHD and 120 (3.1{\%}) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95{\%} CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95{\%} CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95{\%} CI 1.86-3.86; 1.84, 95{\%} CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM. Conclusions: The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy.",
author = "Choi, {Dong Ju} and Yoon, {Chang Hwan} and Heesun Lee and Ahn, {So Yeon} and Oh, {Kyung Joon} and Park, {Hyun Young} and Lee, {Hea Young} and Cho, {Myeong Chan} and Chung, {Ick Mo} and Shin, {Mi Seung} and Park, {Sung Ji} and Shim, {Chi Young} and Han, {Seong Woo} and Chae, {In Ho}",
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Choi, DJ, Yoon, CH, Lee, H, Ahn, SY, Oh, KJ, Park, HY, Lee, HY, Cho, MC, Chung, IM, Shin, MS, Park, SJ, Shim, CY, Han, SW & Chae, IH 2016, 'The association of family history of premature cardiovascular disease or diabetes mellitus on the occurrence of gestational hypertensive disease and diabetes', PloS one, vol. 11, no. 12, e0167528. https://doi.org/10.1371/journal.pone.0167528

The association of family history of premature cardiovascular disease or diabetes mellitus on the occurrence of gestational hypertensive disease and diabetes. / Choi, Dong Ju; Yoon, Chang Hwan; Lee, Heesun; Ahn, So Yeon; Oh, Kyung Joon; Park, Hyun Young; Lee, Hea Young; Cho, Myeong Chan; Chung, Ick Mo; Shin, Mi Seung; Park, Sung Ji; Shim, Chi Young; Han, Seong Woo; Chae, In Ho.

In: PloS one, Vol. 11, No. 12, e0167528, 01.12.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association of family history of premature cardiovascular disease or diabetes mellitus on the occurrence of gestational hypertensive disease and diabetes

AU - Choi, Dong Ju

AU - Yoon, Chang Hwan

AU - Lee, Heesun

AU - Ahn, So Yeon

AU - Oh, Kyung Joon

AU - Park, Hyun Young

AU - Lee, Hea Young

AU - Cho, Myeong Chan

AU - Chung, Ick Mo

AU - Shin, Mi Seung

AU - Park, Sung Ji

AU - Shim, Chi Young

AU - Han, Seong Woo

AU - Chae, In Ho

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. Methods: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual. Results: In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95% CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95% CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86-3.86; 1.84, 95% CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM. Conclusions: The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy.

AB - Background: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. Methods: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual. Results: In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95% CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95% CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86-3.86; 1.84, 95% CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM. Conclusions: The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy.

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