Abstract
Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330–6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790–14.298; p<0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.
| Original language | English |
|---|---|
| Pages (from-to) | 442-446 |
| Number of pages | 5 |
| Journal | Investigative and clinical urology |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 Nov |
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All Science Journal Classification (ASJC) codes
- Urology
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The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population. / Park, Jee Soo; Koo, Kyo Chul; Chung, Byung Ha; Lee, Kwang Suk.
In: Investigative and clinical urology, Vol. 60, No. 6, 11.2019, p. 442-446.Research output: Contribution to journal › Article
TY - JOUR
T1 - The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population
AU - Park, Jee Soo
AU - Koo, Kyo Chul
AU - Chung, Byung Ha
AU - Lee, Kwang Suk
PY - 2019/11
Y1 - 2019/11
N2 - Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330–6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790–14.298; p<0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.
AB - Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330–6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790–14.298; p<0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.
UR - http://www.scopus.com/inward/record.url?scp=85074694600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074694600&partnerID=8YFLogxK
U2 - 10.4111/icu.2019.60.6.442
DO - 10.4111/icu.2019.60.6.442
M3 - Article
C2 - 31692911
AN - SCOPUS:85074694600
VL - 60
SP - 442
EP - 446
JO - Investigative and Clinical Urology
JF - Investigative and Clinical Urology
SN - 2466-0493
IS - 6
ER -