The association of lymphopenia with the clinical severity in the Korean children admitted to the hospital with pandemic (H1N1) 2009 infection

Jin Kyong Chun, Byung Ho Cha, Young Uh, Hyo Youl Kim, YoungKeun Kim, Woocheol Kwon, Hwang Min Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Critical illness due to pandemic (H1N1) 2009 is an emerging threat to global health. In this study, lymphopenia was focused on as a major risk factor for a critical clinical course of pandemic (H1N1) 2009 infection. We investigated the association of lymphopenia at the time of admission with the clinical severity of the admitted children with pandemic (H1N1) 2009 infection. Material and Methods: We performed a retrospective study on the patients who were younger than 15 years of age and who were admitted to Wonju Christian Hospital due to pandemic (H1N1) 2009 infection between August 20, 2009 and February 20, 2010. Pandemic (H1N1) 2009 infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) in all patients. We divided the study period into two periods as August 20 -November 30 2009 (pre-vaccination period) and December 1 2009- February 20 2010 (post-vaccination period). The clinical differences between two periods were analyzed. To define the role of lymphopenia, we examined the differences of clinical manifestations between the H1N1 patients with lymphopenia and those without lymphopenia. Results: Among the 2,399 children who had H1N1 infection, 149 patients (6.2%) were admitted under the following diagnoses: pneumonia (67.1%), bronchiolitis/ asthma (18.8%), croup (6%) and febrile convulsion (8.7%). The median age of the patients was signifi cantly different between during the pre-vaccination period and the post-vaccination period (6 years of age [range: 0.25-14] vs. 3 years of age, [range: 0.1-14], P<0.05). The proportion of patients who had lymphopenia was signifi cantly different between two periods (39.5% vs. 20%, P<0.05). When we compared the clinical severity between the patients with lymphopenia and those without lymphopenia, age (P<0.0001), the length of hospital stay (P<0.0001) and the serum levels of C-reactive protein (P<0.01) were signifi cantly different. Conclusion: Our data support that lymphopenia may be a major determining factor that could cause a critical clinical course during pandemic period among children in the Republic of Korea.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalInfection and Chemotherapy
Volume43
Issue number1
DOIs
Publication statusPublished - 2011 Feb 1

Fingerprint

Lymphopenia
Pandemics
Infection
Vaccination
Length of Stay
Croup
Febrile Seizures
Republic of Korea
Bronchiolitis
Reverse Transcriptase Polymerase Chain Reaction
Critical Illness
C-Reactive Protein
Pneumonia
Asthma
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Chun, Jin Kyong ; Cha, Byung Ho ; Uh, Young ; Kim, Hyo Youl ; Kim, YoungKeun ; Kwon, Woocheol ; Kim, Hwang Min. / The association of lymphopenia with the clinical severity in the Korean children admitted to the hospital with pandemic (H1N1) 2009 infection. In: Infection and Chemotherapy. 2011 ; Vol. 43, No. 1. pp. 36-41.
@article{d62685ca9387492eb42e3b06db1a70c2,
title = "The association of lymphopenia with the clinical severity in the Korean children admitted to the hospital with pandemic (H1N1) 2009 infection",
abstract = "Background: Critical illness due to pandemic (H1N1) 2009 is an emerging threat to global health. In this study, lymphopenia was focused on as a major risk factor for a critical clinical course of pandemic (H1N1) 2009 infection. We investigated the association of lymphopenia at the time of admission with the clinical severity of the admitted children with pandemic (H1N1) 2009 infection. Material and Methods: We performed a retrospective study on the patients who were younger than 15 years of age and who were admitted to Wonju Christian Hospital due to pandemic (H1N1) 2009 infection between August 20, 2009 and February 20, 2010. Pandemic (H1N1) 2009 infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) in all patients. We divided the study period into two periods as August 20 -November 30 2009 (pre-vaccination period) and December 1 2009- February 20 2010 (post-vaccination period). The clinical differences between two periods were analyzed. To define the role of lymphopenia, we examined the differences of clinical manifestations between the H1N1 patients with lymphopenia and those without lymphopenia. Results: Among the 2,399 children who had H1N1 infection, 149 patients (6.2{\%}) were admitted under the following diagnoses: pneumonia (67.1{\%}), bronchiolitis/ asthma (18.8{\%}), croup (6{\%}) and febrile convulsion (8.7{\%}). The median age of the patients was signifi cantly different between during the pre-vaccination period and the post-vaccination period (6 years of age [range: 0.25-14] vs. 3 years of age, [range: 0.1-14], P<0.05). The proportion of patients who had lymphopenia was signifi cantly different between two periods (39.5{\%} vs. 20{\%}, P<0.05). When we compared the clinical severity between the patients with lymphopenia and those without lymphopenia, age (P<0.0001), the length of hospital stay (P<0.0001) and the serum levels of C-reactive protein (P<0.01) were signifi cantly different. Conclusion: Our data support that lymphopenia may be a major determining factor that could cause a critical clinical course during pandemic period among children in the Republic of Korea.",
author = "Chun, {Jin Kyong} and Cha, {Byung Ho} and Young Uh and Kim, {Hyo Youl} and YoungKeun Kim and Woocheol Kwon and Kim, {Hwang Min}",
year = "2011",
month = "2",
day = "1",
doi = "10.3947/ic.2011.43.1.36",
language = "English",
volume = "43",
pages = "36--41",
journal = "Infection and Chemotherapy",
issn = "2093-2340",
publisher = "Taehan Kamyom Hakhoe, Taehan Hwahak Yopop Hakhoe",
number = "1",

}

The association of lymphopenia with the clinical severity in the Korean children admitted to the hospital with pandemic (H1N1) 2009 infection. / Chun, Jin Kyong; Cha, Byung Ho; Uh, Young; Kim, Hyo Youl; Kim, YoungKeun; Kwon, Woocheol; Kim, Hwang Min.

In: Infection and Chemotherapy, Vol. 43, No. 1, 01.02.2011, p. 36-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association of lymphopenia with the clinical severity in the Korean children admitted to the hospital with pandemic (H1N1) 2009 infection

AU - Chun, Jin Kyong

AU - Cha, Byung Ho

AU - Uh, Young

AU - Kim, Hyo Youl

AU - Kim, YoungKeun

AU - Kwon, Woocheol

AU - Kim, Hwang Min

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Critical illness due to pandemic (H1N1) 2009 is an emerging threat to global health. In this study, lymphopenia was focused on as a major risk factor for a critical clinical course of pandemic (H1N1) 2009 infection. We investigated the association of lymphopenia at the time of admission with the clinical severity of the admitted children with pandemic (H1N1) 2009 infection. Material and Methods: We performed a retrospective study on the patients who were younger than 15 years of age and who were admitted to Wonju Christian Hospital due to pandemic (H1N1) 2009 infection between August 20, 2009 and February 20, 2010. Pandemic (H1N1) 2009 infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) in all patients. We divided the study period into two periods as August 20 -November 30 2009 (pre-vaccination period) and December 1 2009- February 20 2010 (post-vaccination period). The clinical differences between two periods were analyzed. To define the role of lymphopenia, we examined the differences of clinical manifestations between the H1N1 patients with lymphopenia and those without lymphopenia. Results: Among the 2,399 children who had H1N1 infection, 149 patients (6.2%) were admitted under the following diagnoses: pneumonia (67.1%), bronchiolitis/ asthma (18.8%), croup (6%) and febrile convulsion (8.7%). The median age of the patients was signifi cantly different between during the pre-vaccination period and the post-vaccination period (6 years of age [range: 0.25-14] vs. 3 years of age, [range: 0.1-14], P<0.05). The proportion of patients who had lymphopenia was signifi cantly different between two periods (39.5% vs. 20%, P<0.05). When we compared the clinical severity between the patients with lymphopenia and those without lymphopenia, age (P<0.0001), the length of hospital stay (P<0.0001) and the serum levels of C-reactive protein (P<0.01) were signifi cantly different. Conclusion: Our data support that lymphopenia may be a major determining factor that could cause a critical clinical course during pandemic period among children in the Republic of Korea.

AB - Background: Critical illness due to pandemic (H1N1) 2009 is an emerging threat to global health. In this study, lymphopenia was focused on as a major risk factor for a critical clinical course of pandemic (H1N1) 2009 infection. We investigated the association of lymphopenia at the time of admission with the clinical severity of the admitted children with pandemic (H1N1) 2009 infection. Material and Methods: We performed a retrospective study on the patients who were younger than 15 years of age and who were admitted to Wonju Christian Hospital due to pandemic (H1N1) 2009 infection between August 20, 2009 and February 20, 2010. Pandemic (H1N1) 2009 infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) in all patients. We divided the study period into two periods as August 20 -November 30 2009 (pre-vaccination period) and December 1 2009- February 20 2010 (post-vaccination period). The clinical differences between two periods were analyzed. To define the role of lymphopenia, we examined the differences of clinical manifestations between the H1N1 patients with lymphopenia and those without lymphopenia. Results: Among the 2,399 children who had H1N1 infection, 149 patients (6.2%) were admitted under the following diagnoses: pneumonia (67.1%), bronchiolitis/ asthma (18.8%), croup (6%) and febrile convulsion (8.7%). The median age of the patients was signifi cantly different between during the pre-vaccination period and the post-vaccination period (6 years of age [range: 0.25-14] vs. 3 years of age, [range: 0.1-14], P<0.05). The proportion of patients who had lymphopenia was signifi cantly different between two periods (39.5% vs. 20%, P<0.05). When we compared the clinical severity between the patients with lymphopenia and those without lymphopenia, age (P<0.0001), the length of hospital stay (P<0.0001) and the serum levels of C-reactive protein (P<0.01) were signifi cantly different. Conclusion: Our data support that lymphopenia may be a major determining factor that could cause a critical clinical course during pandemic period among children in the Republic of Korea.

UR - http://www.scopus.com/inward/record.url?scp=84862879519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862879519&partnerID=8YFLogxK

U2 - 10.3947/ic.2011.43.1.36

DO - 10.3947/ic.2011.43.1.36

M3 - Article

VL - 43

SP - 36

EP - 41

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

SN - 2093-2340

IS - 1

ER -